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• W2024946189 abstract "Human carcinoma cells (NHIK 3025 cells) and Chinese hamster cells (V79 cells) were incubated with AIPcS1, AIPcS2 and AIPcS4, phthalocyanines with different lipophilicity but with similar photochemical properties when in monomeric solutions. The absorption- and fluorescence spectra of the dyes in the cells were recorded as well as their action spectra with respect to sensitizing cells to photoinactivation. These spectra show that under the present conditions AIPcS1 is strongly aggregated in both cell lines; AIPcS2 is aggregated in V79 cells but much less so in NHIK 3025 cells. A main finding is that the shapes of the action spectra are similar to that of the fluorescence excitation spectra, but not to the absorption spectra, indicating that the photosensitizing effects of the dyes are mainly due to their monomeric fraction in the cells. AIPcS2 and AIPcS4 localize intracellularly mainly in lysosomes while AIPcS1 was found to be more diffusely distributed in cells. As measured per quantum of fluorescence emitted, AIPcS2 and AIPcS2 are more efficient sensitizers than AIPcS4. The difference in efficiency between AIPcS2 and AIPcS4 is supposedly due to a different localization pattern on the suborganelle level." @default.
• W2024946189 created "2016-06-24" @default.
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• W2024946189 date "1992-08-01" @default.
• W2024946189 modified "2023-10-09" @default.
• W2024946189 title "ACTION SPECTRA OF PHTHALOCYANINES WITH RESPECT TO PHOTOSENSITIZATION OF CELLS" @default.
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• W2024946189 doi "https://doi.org/10.1111/j.1751-1097.1992.tb02144.x" @default.
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