FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024946584> ?p ?o ?g. }

• W2024946584 endingPage "168" @default.
• W2024946584 startingPage "161" @default.
• W2024946584 abstract "Clinical studies have shown that angiotensin-receptor blockers (ARBs) reduce the risk of cardiovascular diseases in hypertensive patients. It is assumed that the reduction of the risk by ARBs may be attributed in part to the inhibition of angiotensin II (AII)-induced vascular smooth muscle cell (VSMC) migration associated with atherosclerosis. However, the effect of ARBs on AII-induced changes in intracellular signaling and resultant cell migration has not been well established. Here, we investigated the effect of olmesartan, an ARB, on AII-induced extracellular signal–regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) activation and rat aortic smooth muscle cell (RASMC) migration. Olmesartan inhibited AII-induced ERK1/2 and JNK activation at lower concentrations (10 nM). On the other hand, PP2, a Src tyrosine kinase inhibitor, also inhibited AII-induced ERK1/2 and JNK activation, but its effect on ERK1/2 was less pronounced than that of olmesartan. Olmesartan, U0126 (an ERK1/2 inhibitor), SP600125 (a JNK inhibitor), and PP2 potently inhibited AII-induced RASMC migration. From these findings, it was inferred that angiotensin-receptor blockade by olmesartan results in the inhibition of AII-induced activation of Src, ERK1/2, and JNK in RASMC. Olmesartan may be a potent inhibitor of AII-induced VSMC migration, which may be involved in the progression of atherosclerosis." @default.
• W2024946584 created "2016-06-24" @default.
• W2024946584 creator A5041699761 @default.
• W2024946584 creator A5044132578 @default.
• W2024946584 creator A5048984016 @default.
• W2024946584 creator A5068141885 @default.
• W2024946584 creator A5077803439 @default.
• W2024946584 creator A5081167835 @default.
• W2024946584 creator A5085591909 @default.
• W2024946584 date "2010-01-01" @default.
• W2024946584 modified "2023-09-23" @default.
• W2024946584 title "Olmesartan Inhibits Angiotensin II–Induced Migration of Vascular Smooth Muscle Cells Through Src and Mitogen-Activated Protein Kinase Pathways" @default.
• W2024946584 cites W1497461844 @default.
• W2024946584 cites W1555266940 @default.
• W2024946584 cites W1593069239 @default.
• W2024946584 cites W180946569 @default.
• W2024946584 cites W1966931906 @default.
• W2024946584 cites W1969606022 @default.
• W2024946584 cites W1979030376 @default.
• W2024946584 cites W1981409666 @default.
• W2024946584 cites W2002234003 @default.
• W2024946584 cites W2007349364 @default.
• W2024946584 cites W2015807922 @default.
• W2024946584 cites W2028691987 @default.
• W2024946584 cites W2056976690 @default.
• W2024946584 cites W2057764792 @default.
• W2024946584 cites W2080831197 @default.
• W2024946584 cites W2094772268 @default.
• W2024946584 cites W2097665925 @default.
• W2024946584 cites W2098780362 @default.
• W2024946584 cites W2099667017 @default.
• W2024946584 cites W2112662230 @default.
• W2024946584 cites W2129301938 @default.
• W2024946584 cites W2132620114 @default.
• W2024946584 cites W2133217116 @default.
• W2024946584 cites W2155866739 @default.
• W2024946584 cites W2156835140 @default.
• W2024946584 cites W2159929332 @default.
• W2024946584 cites W2160654062 @default.
• W2024946584 cites W2175466008 @default.
• W2024946584 cites W2305118939 @default.
• W2024946584 cites W3021250193 @default.
• W2024946584 doi "https://doi.org/10.1254/jphs.09332fp" @default.
• W2024946584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20508392" @default.
• W2024946584 hasPublicationYear "2010" @default.
• W2024946584 type Work @default.
• W2024946584 sameAs 2024946584 @default.
• W2024946584 citedByCount "24" @default.
• W2024946584 countsByYear W20249465842012 @default.
• W2024946584 countsByYear W20249465842013 @default.
• W2024946584 countsByYear W20249465842014 @default.
• W2024946584 countsByYear W20249465842015 @default.
• W2024946584 countsByYear W20249465842017 @default.
• W2024946584 countsByYear W20249465842018 @default.
• W2024946584 countsByYear W20249465842019 @default.
• W2024946584 countsByYear W20249465842020 @default.
• W2024946584 countsByYear W20249465842021 @default.
• W2024946584 crossrefType "journal-article" @default.
• W2024946584 hasAuthorship W2024946584A5041699761 @default.
• W2024946584 hasAuthorship W2024946584A5044132578 @default.
• W2024946584 hasAuthorship W2024946584A5048984016 @default.
• W2024946584 hasAuthorship W2024946584A5068141885 @default.
• W2024946584 hasAuthorship W2024946584A5077803439 @default.
• W2024946584 hasAuthorship W2024946584A5081167835 @default.
• W2024946584 hasAuthorship W2024946584A5085591909 @default.
• W2024946584 hasBestOaLocation W20249465841 @default.
• W2024946584 hasConcept C104849204 @default.
• W2024946584 hasConcept C108636557 @default.
• W2024946584 hasConcept C121608353 @default.
• W2024946584 hasConcept C123915805 @default.
• W2024946584 hasConcept C126322002 @default.
• W2024946584 hasConcept C132149769 @default.
• W2024946584 hasConcept C134018914 @default.
• W2024946584 hasConcept C170493617 @default.
• W2024946584 hasConcept C184235292 @default.
• W2024946584 hasConcept C185592680 @default.
• W2024946584 hasConcept C2778820342 @default.
• W2024946584 hasConcept C2779395532 @default.
• W2024946584 hasConcept C2779766728 @default.
• W2024946584 hasConcept C2908929049 @default.
• W2024946584 hasConcept C2992686903 @default.
• W2024946584 hasConcept C42362537 @default.
• W2024946584 hasConcept C55493867 @default.
• W2024946584 hasConcept C71924100 @default.
• W2024946584 hasConcept C84393581 @default.
• W2024946584 hasConcept C86803240 @default.
• W2024946584 hasConcept C95444343 @default.
• W2024946584 hasConcept C98274493 @default.
• W2024946584 hasConceptScore W2024946584C104849204 @default.
• W2024946584 hasConceptScore W2024946584C108636557 @default.
• W2024946584 hasConceptScore W2024946584C121608353 @default.
• W2024946584 hasConceptScore W2024946584C123915805 @default.
• W2024946584 hasConceptScore W2024946584C126322002 @default.
• W2024946584 hasConceptScore W2024946584C132149769 @default.
• W2024946584 hasConceptScore W2024946584C134018914 @default.
• W2024946584 hasConceptScore W2024946584C170493617 @default.
• W2024946584 hasConceptScore W2024946584C184235292 @default.
• W2024946584 hasConceptScore W2024946584C185592680 @default.

• next