FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024947590> ?p ?o ?g. }

• W2024947590 endingPage "496" @default.
• W2024947590 startingPage "487" @default.
• W2024947590 abstract "Artemisia asiatica Nakai (Compositae) is a representative herbal plant used to treat infection and inflammatory diseases. Although Artemisia asiatica is reported to have immunopharmacological activities, the mechanisms of these activities and the effectiveness of Artemisia asiatica preparations in use are not known. To evaluate the anti-inflammatory activities of Artemisia asiatica ethanol extract (Aa-EE), we assayed nitric oxide (NO), tumor necrosis factor (TNF)-α, and prostaglandin E2 (PGE2) in macrophages and measured the extent of tissue injury in a model of gastric ulcer induced in mice by treatment with HCl in EtOH. Putative enzymatic mediators of Aa-EE activities were identified by nuclear fractionation, reporter gene assay, immuoprecipitation, immunoblotting, and kinase assay. Active compound in Aa-EE was identified using HPLC. Treatment of RAW264.7 cells and peritoneal macrophages with Aa-EE suppressed the production of NO, PGE2, and TNF-α in response to lipopolysaccharide (LPS) and induced heme oxygenase-1 expression. The Aa-EE also ameliorated symptoms of gastric ulcer in HCl/EtOH-treated mice. These effects were associated with the inhibition of nuclear translocation of nuclear factor (NF)-κB and activator protein (AP)-1, implying that the anti-inflammatory action of the Aa-EE occurred through transcriptional inhibition. The upstream regulatory signals Syk and Src for translocation of NF-κB and TRAF6 for AP-1 were identified as targets of this effect. Analysis of Aa-EE by HPLC revealed the presence of luteolin, known to inhibit NO and PGE2 activity. The anti-inflammatory activities attributed to Artemisia asiatica Nakai in traditional medicine may be mediated by luteolin through inhibition of Src/Syk/NF-κB and TRAF6/JNK/AP-1 signaling pathways." @default.
• W2024947590 created "2016-06-24" @default.
• W2024947590 creator A5001534001 @default.
• W2024947590 creator A5005992782 @default.
• W2024947590 creator A5018777808 @default.
• W2024947590 creator A5020560574 @default.
• W2024947590 creator A5021794448 @default.
• W2024947590 creator A5031317974 @default.
• W2024947590 creator A5031823786 @default.
• W2024947590 creator A5045113357 @default.
• W2024947590 creator A5053603347 @default.
• W2024947590 creator A5056989509 @default.
• W2024947590 creator A5070893429 @default.
• W2024947590 creator A5085027922 @default.
• W2024947590 creator A5088362162 @default.
• W2024947590 date "2014-03-01" @default.
• W2024947590 modified "2023-10-18" @default.
• W2024947590 title "Anti-inflammatory activities and mechanisms of Artemisia asiatica ethanol extract" @default.
• W2024947590 cites W1930485256 @default.
• W2024947590 cites W1963995327 @default.
• W2024947590 cites W1967182826 @default.
• W2024947590 cites W1968316822 @default.
• W2024947590 cites W1973058491 @default.
• W2024947590 cites W1980147332 @default.
• W2024947590 cites W1984252215 @default.
• W2024947590 cites W1988652043 @default.
• W2024947590 cites W1989256429 @default.
• W2024947590 cites W1990802251 @default.
• W2024947590 cites W1993220508 @default.
• W2024947590 cites W1995575093 @default.
• W2024947590 cites W1997065959 @default.
• W2024947590 cites W1997359763 @default.
• W2024947590 cites W1999979392 @default.
• W2024947590 cites W2002093089 @default.
• W2024947590 cites W2002334007 @default.
• W2024947590 cites W2003574070 @default.
• W2024947590 cites W2006778209 @default.
• W2024947590 cites W2008570185 @default.
• W2024947590 cites W2010466302 @default.
• W2024947590 cites W2016169910 @default.
• W2024947590 cites W2025893393 @default.
• W2024947590 cites W2028927816 @default.
• W2024947590 cites W2028933316 @default.
• W2024947590 cites W2030831465 @default.
• W2024947590 cites W2031155523 @default.
• W2024947590 cites W2033836926 @default.
• W2024947590 cites W2039905002 @default.
• W2024947590 cites W2043609259 @default.
• W2024947590 cites W2047313618 @default.
• W2024947590 cites W2049097879 @default.
• W2024947590 cites W2050107072 @default.
• W2024947590 cites W2052898023 @default.
• W2024947590 cites W2056858340 @default.
• W2024947590 cites W2057325004 @default.
• W2024947590 cites W2057776973 @default.
• W2024947590 cites W2059174274 @default.
• W2024947590 cites W2066079783 @default.
• W2024947590 cites W2067897460 @default.
• W2024947590 cites W2070648014 @default.
• W2024947590 cites W2074975005 @default.
• W2024947590 cites W2075034776 @default.
• W2024947590 cites W2077029966 @default.
• W2024947590 cites W2077388980 @default.
• W2024947590 cites W2096882069 @default.
• W2024947590 cites W2106527017 @default.
• W2024947590 cites W2106908363 @default.
• W2024947590 cites W2108362964 @default.
• W2024947590 cites W2110857998 @default.
• W2024947590 cites W2115195989 @default.
• W2024947590 cites W2118424828 @default.
• W2024947590 cites W2120412340 @default.
• W2024947590 cites W2126537721 @default.
• W2024947590 cites W2134237689 @default.
• W2024947590 cites W2153071302 @default.
• W2024947590 cites W2155135949 @default.
• W2024947590 cites W2915573764 @default.
• W2024947590 doi "https://doi.org/10.1016/j.jep.2014.01.030" @default.
• W2024947590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24503036" @default.
• W2024947590 hasPublicationYear "2014" @default.
• W2024947590 type Work @default.
• W2024947590 sameAs 2024947590 @default.
• W2024947590 citedByCount "63" @default.
• W2024947590 countsByYear W20249475902014 @default.
• W2024947590 countsByYear W20249475902015 @default.
• W2024947590 countsByYear W20249475902016 @default.
• W2024947590 countsByYear W20249475902017 @default.
• W2024947590 countsByYear W20249475902018 @default.
• W2024947590 countsByYear W20249475902019 @default.
• W2024947590 countsByYear W20249475902020 @default.
• W2024947590 countsByYear W20249475902021 @default.
• W2024947590 countsByYear W20249475902022 @default.
• W2024947590 countsByYear W20249475902023 @default.
• W2024947590 crossrefType "journal-article" @default.
• W2024947590 hasAuthorship W2024947590A5001534001 @default.
• W2024947590 hasAuthorship W2024947590A5005992782 @default.
• W2024947590 hasAuthorship W2024947590A5018777808 @default.
• W2024947590 hasAuthorship W2024947590A5020560574 @default.
• W2024947590 hasAuthorship W2024947590A5021794448 @default.

• next