Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024950051> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W2024950051 endingPage "157" @default.
- W2024950051 startingPage "157" @default.
- W2024950051 abstract "Synapses mediate information flow between neurons and undergo plastic changes in response to experience, which is critical for learning and memory. Conversely, synaptic defects impair information processing and underlie many brain pathologies. Rho-family GTPases control synaptogenesis by transducing signals from extracellular stimuli to the cytoskeleton and nucleus. The Rho-GTPases Rac1 and Cdc42 promote synapse development and the growth of axons and dendrites, while RhoA antagonizes these processes. Despite its importance, many aspects of Rho-GTPase signaling remain relatively unknown. Rho-GTPases are activated by guanine nucleotide exchange factors (GEFs) and inhibited by GTPase-activating proteins (GAPs). Though the number of both GEFs and GAPs greatly exceeds that of Rho-GTPases, loss of even a single GEF or GAP often has profound effects on cognition and behavior. Here, we explore how the actions of specific GEFs and GAPs give rise to the precise spatiotemporal activation patterns of Rho-GTPases in neurons. We consider the effects of coupling GEFs and GAPs targeting the same Rho-GTPase and the modular pathways that connect specific cellular stimuli with a given Rho-GTPase via different GEFs. We discuss how the creation of sharp borders between Rho-GTPase activation zones is achieved by pairing a GEF for one Rho-GTPase with a GAP for another and the extensive crosstalk between different Rho-GTPases. Given the importance of synapses for cognition and the fundamental roles that Rho-GTPases play in regulating them, a detailed understanding of Rho-GTPase signaling is essential to the progress of neuroscience." @default.
- W2024950051 created "2016-06-24" @default.
- W2024950051 creator A5050329168 @default.
- W2024950051 date "2010-06-01" @default.
- W2024950051 modified "2023-10-18" @default.
- W2024950051 title "616 Sequencing cancer genomes" @default.
- W2024950051 doi "https://doi.org/10.1016/s1359-6349(10)71417-8" @default.
- W2024950051 hasPublicationYear "2010" @default.
- W2024950051 type Work @default.
- W2024950051 sameAs 2024950051 @default.
- W2024950051 citedByCount "0" @default.
- W2024950051 crossrefType "journal-article" @default.
- W2024950051 hasAuthorship W2024950051A5050329168 @default.
- W2024950051 hasConcept C120665830 @default.
- W2024950051 hasConcept C121332964 @default.
- W2024950051 hasConcept C126619667 @default.
- W2024950051 hasConcept C169760540 @default.
- W2024950051 hasConcept C169822122 @default.
- W2024950051 hasConcept C207332259 @default.
- W2024950051 hasConcept C2777093181 @default.
- W2024950051 hasConcept C2780040266 @default.
- W2024950051 hasConcept C62478195 @default.
- W2024950051 hasConcept C86803240 @default.
- W2024950051 hasConcept C95444343 @default.
- W2024950051 hasConceptScore W2024950051C120665830 @default.
- W2024950051 hasConceptScore W2024950051C121332964 @default.
- W2024950051 hasConceptScore W2024950051C126619667 @default.
- W2024950051 hasConceptScore W2024950051C169760540 @default.
- W2024950051 hasConceptScore W2024950051C169822122 @default.
- W2024950051 hasConceptScore W2024950051C207332259 @default.
- W2024950051 hasConceptScore W2024950051C2777093181 @default.
- W2024950051 hasConceptScore W2024950051C2780040266 @default.
- W2024950051 hasConceptScore W2024950051C62478195 @default.
- W2024950051 hasConceptScore W2024950051C86803240 @default.
- W2024950051 hasConceptScore W2024950051C95444343 @default.
- W2024950051 hasIssue "5" @default.
- W2024950051 hasLocation W20249500511 @default.
- W2024950051 hasOpenAccess W2024950051 @default.
- W2024950051 hasPrimaryLocation W20249500511 @default.
- W2024950051 hasRelatedWork W1555349201 @default.
- W2024950051 hasRelatedWork W1978792584 @default.
- W2024950051 hasRelatedWork W1993756444 @default.
- W2024950051 hasRelatedWork W2024427215 @default.
- W2024950051 hasRelatedWork W2111245936 @default.
- W2024950051 hasRelatedWork W2144323830 @default.
- W2024950051 hasRelatedWork W2162049443 @default.
- W2024950051 hasRelatedWork W2593231720 @default.
- W2024950051 hasRelatedWork W2768843258 @default.
- W2024950051 hasRelatedWork W3159696590 @default.
- W2024950051 hasVolume "8" @default.
- W2024950051 isParatext "false" @default.
- W2024950051 isRetracted "false" @default.
- W2024950051 magId "2024950051" @default.
- W2024950051 workType "article" @default.