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• W2024952105 abstract "Gonadal function and histology were studied in seven male patients who received cyclophosphamide for treatment of nephrotic syndrome prior to or during puberty. Treatment ranged from six weeks to 19 months and the total doses of cyclophosphamide varied from 18.0 to 39.0 Gm. One to four years following cessation of therapy, two patients had normal testicular function, four were azoospermic, and one oligospermic. Testicular biopsies confirmed absence of spermatogenesis in the azoospermic patients. Secondary sex characteristics were normal in all patients, although one patient had diminished testicular size. Serum follicle-stimulating hormone (FSH), luteninizing hormone (LH), and testosterone were measured on all patients; FSH elevation appeared to correspond to the degree of testicular damage. Gonadal function and histology were studied in seven male patients who received cyclophosphamide for treatment of nephrotic syndrome prior to or during puberty. Treatment ranged from six weeks to 19 months and the total doses of cyclophosphamide varied from 18.0 to 39.0 Gm. One to four years following cessation of therapy, two patients had normal testicular function, four were azoospermic, and one oligospermic. Testicular biopsies confirmed absence of spermatogenesis in the azoospermic patients. Secondary sex characteristics were normal in all patients, although one patient had diminished testicular size. Serum follicle-stimulating hormone (FSH), luteninizing hormone (LH), and testosterone were measured on all patients; FSH elevation appeared to correspond to the degree of testicular damage." @default.
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• W2024952105 date "1974-06-01" @default.
• W2024952105 modified "2023-09-27" @default.
• W2024952105 title "Testicular function in prepubertal and pubertal male patients treated with cyclophosphamide for nephrotic syndrome" @default.
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• W2024952105 doi "https://doi.org/10.1016/s0022-3476(74)80758-4" @default.
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