FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024952531> ?p ?o ?g. }

• W2024952531 endingPage "628" @default.
• W2024952531 startingPage "622" @default.
• W2024952531 abstract "1 Full length clones of the human 5-HT2B receptor were isolated from human liver, kidney and pancreas. The cloned human 5-HT2B receptors had a high degree of homology (∼80%) with the rat and mouse 5-HT2B receptors. 2 PCR amplification was used to determine the tissue distribution of human 5-HT2B receptor mRNA. mRNA encoding the 5-HT2B receptor was expressed with greatest abundance in human liver and kidney. Lower levels of expression were detected in cerebral cortex, whole brain, pancreas and spleen. Expression was not detected in heart. 3 Northern blot analysis confirmed the presence of 5-HT2B receptor mRNA (a 2.4 kB sized band) in pancreas, liver and kidney. An additional 3.2 kB sized band of hybridization was detected in liver and kidney. This raises the possibility of a splice variant of the receptor or the presence of an additional homologous receptor. 4 The human 5-HT2B receptor was expressed in Cos-7 cells and its ligand binding characteristics were compared to similarly expressed human 5-HT2A and 5-HT2C receptors. The ligand specificity of the human 5-HT2B receptor (5-HT > ritanserin > SB 204741 > spiperone) was distinct from that of the human 5-HT2A (ritanserin > spiperone > 5-HT > SB 204741) and 5-HT2C (ritanserin > 5-HT > spiperone = SB 204741) receptors. On the basis of a higher affinity for ketanserin and a lower affinity for yohimbine the human 5-HT2B receptor also appeared to differ from the rat 5-HT2B receptor. 5 These findings confirm the sequence of the human 5-HT2B receptor and they demonstrate that the receptor has a widespread tissue distribution. In addition, these data suggest that there are differences in ligand affinities between different species homologues of the receptor. Finally, the finding of two distinct bands on the Northern blots of liver and kidney raises the possibility of splice variants or subtypes of 5-HT2B receptors, within these tissues." @default.
• W2024952531 created "2016-06-24" @default.
• W2024952531 creator A5001866590 @default.
• W2024952531 creator A5049654754 @default.
• W2024952531 creator A5054678316 @default.
• W2024952531 creator A5067892621 @default.
• W2024952531 creator A5070529034 @default.
• W2024952531 creator A5072070682 @default.
• W2024952531 creator A5073782356 @default.
• W2024952531 creator A5088105419 @default.
• W2024952531 date "1995-06-01" @default.
• W2024952531 modified "2023-10-10" @default.
• W2024952531 title "The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2b) receptor gene products: comparison with 5-HT2a and 5-HT2c receptors" @default.
• W2024952531 cites W129649145 @default.
• W2024952531 cites W1763330810 @default.
• W2024952531 cites W1766643663 @default.
• W2024952531 cites W1792038761 @default.
• W2024952531 cites W1832715411 @default.
• W2024952531 cites W1921286193 @default.
• W2024952531 cites W1964581139 @default.
• W2024952531 cites W1968303737 @default.
• W2024952531 cites W1970261516 @default.
• W2024952531 cites W1971290197 @default.
• W2024952531 cites W1977862375 @default.
• W2024952531 cites W1980189014 @default.
• W2024952531 cites W1990635904 @default.
• W2024952531 cites W2013386552 @default.
• W2024952531 cites W2036054091 @default.
• W2024952531 cites W2043813981 @default.
• W2024952531 cites W2044799822 @default.
• W2024952531 cites W2051263615 @default.
• W2024952531 cites W2056761692 @default.
• W2024952531 cites W2063085120 @default.
• W2024952531 cites W2063487122 @default.
• W2024952531 cites W2068360184 @default.
• W2024952531 cites W2085482875 @default.
• W2024952531 cites W2093336211 @default.
• W2024952531 cites W2128635872 @default.
• W2024952531 cites W2153853866 @default.
• W2024952531 cites W2292558343 @default.
• W2024952531 cites W4255858411 @default.
• W2024952531 cites W4293247451 @default.
• W2024952531 doi "https://doi.org/10.1111/j.1476-5381.1995.tb14977.x" @default.
• W2024952531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1908489" @default.
• W2024952531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7582481" @default.
• W2024952531 hasPublicationYear "1995" @default.
• W2024952531 type Work @default.
• W2024952531 sameAs 2024952531 @default.
• W2024952531 citedByCount "280" @default.
• W2024952531 countsByYear W20249525312012 @default.
• W2024952531 countsByYear W20249525312013 @default.
• W2024952531 countsByYear W20249525312014 @default.
• W2024952531 countsByYear W20249525312015 @default.
• W2024952531 countsByYear W20249525312016 @default.
• W2024952531 countsByYear W20249525312017 @default.
• W2024952531 countsByYear W20249525312018 @default.
• W2024952531 countsByYear W20249525312019 @default.
• W2024952531 countsByYear W20249525312020 @default.
• W2024952531 countsByYear W20249525312021 @default.
• W2024952531 countsByYear W20249525312022 @default.
• W2024952531 countsByYear W20249525312023 @default.
• W2024952531 crossrefType "journal-article" @default.
• W2024952531 hasAuthorship W2024952531A5001866590 @default.
• W2024952531 hasAuthorship W2024952531A5049654754 @default.
• W2024952531 hasAuthorship W2024952531A5054678316 @default.
• W2024952531 hasAuthorship W2024952531A5067892621 @default.
• W2024952531 hasAuthorship W2024952531A5070529034 @default.
• W2024952531 hasAuthorship W2024952531A5072070682 @default.
• W2024952531 hasAuthorship W2024952531A5073782356 @default.
• W2024952531 hasAuthorship W2024952531A5088105419 @default.
• W2024952531 hasBestOaLocation W20249525311 @default.
• W2024952531 hasConcept C126322002 @default.
• W2024952531 hasConcept C134018914 @default.
• W2024952531 hasConcept C153911025 @default.
• W2024952531 hasConcept C170493617 @default.
• W2024952531 hasConcept C17971392 @default.
• W2024952531 hasConcept C200220013 @default.
• W2024952531 hasConcept C2775864247 @default.
• W2024952531 hasConcept C2776885963 @default.
• W2024952531 hasConcept C2777450907 @default.
• W2024952531 hasConcept C2777785214 @default.
• W2024952531 hasConcept C2778122271 @default.
• W2024952531 hasConcept C2781073084 @default.
• W2024952531 hasConcept C53910766 @default.
• W2024952531 hasConcept C55493867 @default.
• W2024952531 hasConcept C71924100 @default.
• W2024952531 hasConcept C86803240 @default.
• W2024952531 hasConceptScore W2024952531C126322002 @default.
• W2024952531 hasConceptScore W2024952531C134018914 @default.
• W2024952531 hasConceptScore W2024952531C153911025 @default.
• W2024952531 hasConceptScore W2024952531C170493617 @default.
• W2024952531 hasConceptScore W2024952531C17971392 @default.
• W2024952531 hasConceptScore W2024952531C200220013 @default.
• W2024952531 hasConceptScore W2024952531C2775864247 @default.
• W2024952531 hasConceptScore W2024952531C2776885963 @default.
• W2024952531 hasConceptScore W2024952531C2777450907 @default.
• W2024952531 hasConceptScore W2024952531C2777785214 @default.
• W2024952531 hasConceptScore W2024952531C2778122271 @default.

• next