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- W2024952816 abstract "TDP-43 proteinopathy (amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions) is a newly categorized group of neurodegenerative disorders characterized by abnormal accumulation and mislocalization of nuclear TDP-43 protein in the neuronal cytoplasm. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is non-enzymatically produced from PGD2 and plays roles in inflammation and oxidative stress responses. Indeed, 15d-PGJ2 is up-regulated in the spinal motor neurons in amyotrophic lateral sclerosis. In this study, biochemical and immunocytochemical analyses showed that 15d-PGJ2 affects the proteolysis, solubility, and subcellular localization of TDP-43, similar to alterations found in TDP-43 proteinopathy. Further studies revealed that a cyclopentenone ring containing an electrophilic carbon of 15d-PGJ2 is likely to influence these phenomena. These findings suggest that 15d-PGJ2 is an endogenous modifier of TDP-43 protein in TDP-43 proteinopathy." @default.
- W2024952816 created "2016-06-24" @default.
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- W2024952816 date "2010-04-01" @default.
- W2024952816 modified "2023-09-25" @default.
- W2024952816 title "Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Δ12,14-prostaglandin J2" @default.
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- W2024952816 doi "https://doi.org/10.1016/j.expneurol.2010.01.007" @default.
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