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• W2024953155 endingPage "343" @default.
• W2024953155 startingPage "330" @default.
• W2024953155 abstract "The crystal structure of the human class III χχ alcohol dehydrogenase (ADH) in a binary complex with NAD+ γ was solved to 2.7 Å resolution by molecular replacement with human class I β1β1 ADH. χχ ADH catalyzes the oxidation of long-chain alcohols such as ω-hydroxy fatty acids as well as S-hydroxymethyl-glutathione, a spontaneous adduct between formal dehyde and glutathione. There are two subunits per asymmetric unit in the χχ ADH structure. Both subunits display a semi-open conformation of the catalytic domain. This conformation is half-way between the open and closed conformations described for the horse EE ADH enzyme. The semi-open conformation and key changes in elements of secondary structure provide a structural basis for the ability of χχ ADH to bind S-hydroxymethyl-glutathione and 10-hydroxydecanoate. Direct coordi nation of the catalytic zinc ion by Glu68 creates a novel environment for the catalytic zinc ion in χχ ADH. This new configuration of the catalytic zinc is similar to an intermediate for horse EE ADH proposed through theoretical computations and is consistent with the spectroscopic data of the Co(II)-substituted χχ enzyme. The position for residue His47 in the χχ ADH structure suggests His47 may function both as a catalytic base for proton transfer and in the binding of the adenosine phosphate of NAD(H). Modeling of substrate binding to this enzyme structure is consistent with prior mutagenesis data which showed that both Asp57 and Arg115 contribute to glutathione binding and that Arg115 contributes to the binding of ω-hydroxy fatty acids and identifies additional residues which may contribute to substrate binding." @default.
• W2024953155 created "2016-06-24" @default.
• W2024953155 creator A5012216399 @default.
• W2024953155 creator A5014286175 @default.
• W2024953155 creator A5031403355 @default.
• W2024953155 date "1997-01-01" @default.
• W2024953155 modified "2023-10-02" @default.
• W2024953155 title "Structure of human χχ alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase" @default.
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• W2024953155 doi "https://doi.org/10.1006/jmbi.1996.0731" @default.
• W2024953155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9018047" @default.
• W2024953155 hasPublicationYear "1997" @default.
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