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- W2024953371 abstract "It has been proposed that long-acting risperidone could provide a constant antipsychotic efficacy associated with a reduced liability to induce extra-pyramidal symptoms. To ascertain this hypothesis, antagonism of amphetamine-induced hyperlocomotion and catalepsy were analyzed in rats for a period of 1–6 weeks following long-acting risperidone (20–60 mg/kg) injection. Long-acting risperidone reduced amphetamine-induced hyperlocomotion after 2–5 weeks from drug injection, without producing significant extra-pyramidal symptoms. Following the administration of long-acting risperidone a constant ability to antagonize amphetamine-induced hyperlocomotion was observed during the day, but not when the antipsychotic was chronically administered using a short-acting formulation. The pre-clinical results confirmed that long-acting risperidone may represent an advance in antipsychotic therapy." @default.
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- W2024953371 date "2009-10-01" @default.
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- W2024953371 title "Evaluation of amphetamine-induced hyperlocomotion and catalepsy following long-acting risperidone administration in rats" @default.
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- W2024953371 doi "https://doi.org/10.1016/j.ejphar.2009.07.024" @default.
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