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• W2024954071 abstract "A range of hamster cell mutants, which have been charaterised as sensitive to ionising radiation, were examined for their cross-sensitivity to four DNA-DNA cross linking agents and the protein-DNA cross-linking agent, camptothecin. The mutants represent 7 distinct complementation groups. Two complementation groups were identified as having a major sensitivity to cross-linking damage, more marked than their sensitivity to ionising radiation (irsl, irs1SF). These two mutants also show sensitivity to UV-irradiation. Two of the remaining complementation groups (xrs and XR-1) have a defect in rejoining DNA double-strand breaks, and these exhibit sensitivity to 3 of the 4 DNA-DNA cross-linking agents. The results with these suggest an involvement of double-strand break rejoining in the repair of certain cross-link damage. Two mutants were also notably sensitivie to the topoisomerase I inhibiting anticancer drug, camptothecin. One of these mutants was sensitive to the DNA cross-linking agents examined (irs1SF), but the other was not at all sensitive to this class of drug (EM9)." @default.
• W2024954071 created "2016-06-24" @default.
• W2024954071 creator A5058322347 @default.
• W2024954071 creator A5078309099 @default.
• W2024954071 date "1991-09-01" @default.
• W2024954071 modified "2023-09-25" @default.
• W2024954071 title "Cross-sensitivity of γ-ray-sensitive hamster mutants to cross-linking agents" @default.
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• W2024954071 doi "https://doi.org/10.1016/0921-8777(91)90046-r" @default.
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