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• W2024954897 abstract "Axon regeneration after injury requires the extensive reconstruction, reorganization, and stabilization of the microtubule cytoskeleton in the growth cones. Here, we identify KIF3C as a key regulator of axonal growth and regeneration by controlling microtubule dynamics and organization in the growth cone. KIF3C is developmentally regulated. Rat embryonic sensory axons and growth cones contain undetectable levels of KIF3C protein that is locally translated immediately after injury. In adult neurons, KIF3C is axonally transported from the cell body and is enriched at the growth cone where it preferentially binds to tyrosinated microtubules. Functionally, the interaction of KIF3C with EB3 is necessary for its localization at the microtubule plus-ends in the growth cone. Depletion of KIF3C in adult neurons leads to an increase in stable, overgrown and looped microtubules because of a strong decrease in the microtubule frequency of catastrophes, suggesting that KIF3C functions as a microtubule-destabilizing factor. Adult axons lacking KIF3C, by RNA interference or <i>KIF3C</i> gene knock-out, display an impaired axonal outgrowth <i>in vitro</i> and a delayed regeneration after injury both <i>in vitro</i> and <i>in vivo.</i> Murine <i>KIF3C</i> knock-out embryonic axons grow normally but do not regenerate after injury because they are unable to locally translate KIF3C. These data show that KIF3C is an injury-specific kinesin that contributes to axon growth and regeneration by regulating and organizing the microtubule cytoskeleton in the growth cone." @default.
• W2024954897 created "2016-06-24" @default.
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• W2024954897 date "2013-07-10" @default.
• W2024954897 modified "2023-10-16" @default.
• W2024954897 title "The Kinesin-2 Family Member KIF3C Regulates Microtubule Dynamics and Is Required for Axon Growth and Regeneration" @default.
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• W2024954897 doi "https://doi.org/10.1523/jneurosci.5221-12.2013" @default.
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