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- W2024956593 abstract "Preincubation of platelet-rich plasma with N-ethylmaleimide (NEM) attenuated the inhibitory effect of the α2-adrenoceptor agonist UK 14304 on basal and forskolin-stimulated adenylate cyclase activities. NEM also led to concomitant marked reductions of the specific binding of [3H]UK 14304 to platelet membranes and of the primary aggregation response induced by UK 14304. These results indicate that uncoupling of the receptor adenylate cyclase system by NEM induces down-regulation of platelet α2-adrenoceptor density (3H-agonist binding sites) and of the associated functional response (platelet aggregation)." @default.
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- W2024956593 date "1988-01-01" @default.
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- W2024956593 title "Uncoupling of the platelet α2-adrenoceptor adenylate cyclase system by N-ethylmaleimide and the resulting effect on receptor density and sensitivity" @default.
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- W2024956593 doi "https://doi.org/10.1016/0014-2999(88)90354-8" @default.
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