FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024956871> ?p ?o ?g. }

• W2024956871 endingPage "177" @default.
• W2024956871 startingPage "171" @default.
• W2024956871 abstract "Cardiotrophin-1 (CT-1) is a cytokine involved in the growth and survival of cardiac cells that stimulates cardiomyogenesis in pluripotent murine embryonic stem (ES) cells. But it is not known whether CT-1 is responsible for the fate of differentiated bone marrow mesenchymal stem cells (BMMSCs).We investigated the effects of CT-1 on differentiation and maturation of BMMSCs in vitro induced with 5-azacytidine. BMMSCs isolated from femur of rats were induced by CT-1 only, by 5-azacytidine with or without CT-1,and an untreated control group was also set. After 4 weeks of induced culturing, we observed the levels of alpha-cardiac actin and troponin-I by immunohistochemical staining, the ultrastructure of induce-cultured BMMSCs, and the expression of GATA4, Nkx2.5, beta-myosin heavy chain (beta-MHC) and alpha-cardiac actin mRNA by real time RT-PCR analysis.Differentiated BMMSCs treated by 5-azacytidine and CT-1 distinctly showed formations of myofilaments and myotube-like structures-morphological characteristics of myocyte like cells, and spontaneous contraction of a few cells was observed. The protein levels of alpha-cardiac actin and troponin-T were significantly higher than control. Furthermore, mRNA expression of GATA4, Nkx2.5, alpha-cardiac actin and beta-MHC was increased remarkably.This study suggests that induced culturing of BMMSCs in the presence of 5-azacytidine combined with CT-1 can enhance cardiomyocytic characteristics. CT-1 upregulates the expression of GATA4, Nkx2-5, alpha-cardiac actin and beta-MHC mRNA, and rapidly promotes the differentiation and maturation of cardiomyocyte-like cells differentiated from BMMSCs induced with 5-azacytidine." @default.
• W2024956871 created "2016-06-24" @default.
• W2024956871 creator A5024722298 @default.
• W2024956871 creator A5036287047 @default.
• W2024956871 creator A5042841689 @default.
• W2024956871 creator A5053417678 @default.
• W2024956871 creator A5062031783 @default.
• W2024956871 creator A5065442049 @default.
• W2024956871 creator A5084528577 @default.
• W2024956871 creator A5085418653 @default.
• W2024956871 date "2010-08-01" @default.
• W2024956871 modified "2023-10-05" @default.
• W2024956871 title "Effects of cardiotrophin-1 on differentiation and maturation of rat bone marrow mesenchymal stem cells induced with 5-azacytidine in vitro" @default.
• W2024956871 cites W1483231863 @default.
• W2024956871 cites W1492344672 @default.
• W2024956871 cites W1856542144 @default.
• W2024956871 cites W1956857062 @default.
• W2024956871 cites W1978109374 @default.
• W2024956871 cites W1980249853 @default.
• W2024956871 cites W1982577203 @default.
• W2024956871 cites W1990156054 @default.
• W2024956871 cites W2003420116 @default.
• W2024956871 cites W2022123949 @default.
• W2024956871 cites W2031161073 @default.
• W2024956871 cites W2064586774 @default.
• W2024956871 cites W2065427776 @default.
• W2024956871 cites W2066695771 @default.
• W2024956871 cites W2072386632 @default.
• W2024956871 cites W2094133290 @default.
• W2024956871 cites W2107688352 @default.
• W2024956871 cites W2114754360 @default.
• W2024956871 cites W2117733917 @default.
• W2024956871 cites W2135801344 @default.
• W2024956871 cites W2149486327 @default.
• W2024956871 cites W2167479184 @default.
• W2024956871 cites W2185606555 @default.
• W2024956871 cites W2615043561 @default.
• W2024956871 cites W323411733 @default.
• W2024956871 cites W72807688 @default.
• W2024956871 doi "https://doi.org/10.1016/j.ijcard.2009.02.009" @default.
• W2024956871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19269704" @default.
• W2024956871 hasPublicationYear "2010" @default.
• W2024956871 type Work @default.
• W2024956871 sameAs 2024956871 @default.
• W2024956871 citedByCount "14" @default.
• W2024956871 countsByYear W20249568712013 @default.
• W2024956871 countsByYear W20249568712015 @default.
• W2024956871 countsByYear W20249568712017 @default.
• W2024956871 countsByYear W20249568712019 @default.
• W2024956871 countsByYear W20249568712020 @default.
• W2024956871 countsByYear W20249568712021 @default.
• W2024956871 crossrefType "journal-article" @default.
• W2024956871 hasAuthorship W2024956871A5024722298 @default.
• W2024956871 hasAuthorship W2024956871A5036287047 @default.
• W2024956871 hasAuthorship W2024956871A5042841689 @default.
• W2024956871 hasAuthorship W2024956871A5053417678 @default.
• W2024956871 hasAuthorship W2024956871A5062031783 @default.
• W2024956871 hasAuthorship W2024956871A5065442049 @default.
• W2024956871 hasAuthorship W2024956871A5084528577 @default.
• W2024956871 hasAuthorship W2024956871A5085418653 @default.
• W2024956871 hasConcept C104317684 @default.
• W2024956871 hasConcept C133702464 @default.
• W2024956871 hasConcept C142669718 @default.
• W2024956871 hasConcept C142724271 @default.
• W2024956871 hasConcept C145103041 @default.
• W2024956871 hasConcept C148738053 @default.
• W2024956871 hasConcept C1491633281 @default.
• W2024956871 hasConcept C153911025 @default.
• W2024956871 hasConcept C198826908 @default.
• W2024956871 hasConcept C202751555 @default.
• W2024956871 hasConcept C203014093 @default.
• W2024956871 hasConcept C207200792 @default.
• W2024956871 hasConcept C2780007613 @default.
• W2024956871 hasConcept C55493867 @default.
• W2024956871 hasConcept C6997183 @default.
• W2024956871 hasConcept C71924100 @default.
• W2024956871 hasConcept C86803240 @default.
• W2024956871 hasConcept C95444343 @default.
• W2024956871 hasConceptScore W2024956871C104317684 @default.
• W2024956871 hasConceptScore W2024956871C133702464 @default.
• W2024956871 hasConceptScore W2024956871C142669718 @default.
• W2024956871 hasConceptScore W2024956871C142724271 @default.
• W2024956871 hasConceptScore W2024956871C145103041 @default.
• W2024956871 hasConceptScore W2024956871C148738053 @default.
• W2024956871 hasConceptScore W2024956871C1491633281 @default.
• W2024956871 hasConceptScore W2024956871C153911025 @default.
• W2024956871 hasConceptScore W2024956871C198826908 @default.
• W2024956871 hasConceptScore W2024956871C202751555 @default.
• W2024956871 hasConceptScore W2024956871C203014093 @default.
• W2024956871 hasConceptScore W2024956871C207200792 @default.
• W2024956871 hasConceptScore W2024956871C2780007613 @default.
• W2024956871 hasConceptScore W2024956871C55493867 @default.
• W2024956871 hasConceptScore W2024956871C6997183 @default.
• W2024956871 hasConceptScore W2024956871C71924100 @default.
• W2024956871 hasConceptScore W2024956871C86803240 @default.
• W2024956871 hasConceptScore W2024956871C95444343 @default.
• W2024956871 hasIssue "2" @default.
• W2024956871 hasLocation W20249568711 @default.

• next