FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024956957> ?p ?o ?g. }

• W2024956957 abstract "1. Experiments were performed in anaesthetized rabbits to examine the effects of calcitonin gene-related peptide (CGRP) and the CGRP antagonist CGRP8-37 on blood flow to the medial collateral ligament of the knee joint. 2. Topical application of CGRP (10(-13) to 10(-9) mol) to the exposed external surface of eight knee joints resulted in dose-dependent dilatation of vessels in both the ligament and the joint capsule. The magnitude of this response varied significantly in different regions of the medial collateral ligament, with the 10(-9) mol dose of CGRP giving the maximum response (101.5 +/- 25.3% increase) at the femoral insertion site of the medial collateral ligament and lowest (23.1 +/- 8.8%) at the tibial insertion site. 3. Topical application of CGRP8-37 (0.1, 1 and 10 nmol) produced dose-dependent constriction of vessels in the ligament and the joint capsule in five knees, with a trend towards the greatest effect occurring at the femoral insertion site (45.8 +/- 8.1% reduction in blood flow). With the 10 nmol dose, the vasoconstrictor response at the femoral insertion site differed significantly (P<0.05) from the responses obtained at the tibial insertion and joint capsule sites. 4. Topical application of CGRP8-37 (0.1, 1 and 10 nmol) to four chronically denervated knees produced substantially smaller vasoconstrictor responses at all sites. At the femoral insertion site, where 10 nmol CGRP8-37 normally produces a 45.8 +/- 8.1% reduction in blood flow (n=8), ten days following denervation this response was reduced to 6.5 +/- 6.1%, this difference being significant (P=0.01). 5. Adrenaline was applied topically to augment blood vessel tone, in order to establish how effectively co-administration of CGRP would offset this increase in tone. Adrenaline (10(-10) mol) produced vasoconstriction at all sites (n=6). In the capsule this vasoconstriction was virtually abolished when CGRP (10(-9) mol) was co-administered with adrenaline but in the ligament vasodilatation occurred at all sites. This vasodilatation was significantly greater at the femoral insertion site compared to the tibial insertion and mid ligament sites (P<0.05 for both) and the capsule (P<0.01). 6. Topical application of substance P (10(-10) or 10(-9) mol) failed to elicit dilatation of ligament blood vessels. 7. These results suggest that endogenous CGRP may play an important role in regulating blood flow to different structures in and around the knee joint." @default.
• W2024956957 created "2016-06-24" @default.
• W2024956957 creator A5004167898 @default.
• W2024956957 creator A5040421110 @default.
• W2024956957 creator A5044498093 @default.
• W2024956957 date "1997-07-01" @default.
• W2024956957 modified "2023-09-23" @default.
• W2024956957 title "Spatial heterogeneity of the effects of calcitonin gene-related peptide (CGRP) on the microvasculature of ligaments in the rabbit knee joint" @default.
• W2024956957 cites W1967795139 @default.
• W2024956957 cites W1968110345 @default.
• W2024956957 cites W1969221593 @default.
• W2024956957 cites W1970854543 @default.
• W2024956957 cites W1975828201 @default.
• W2024956957 cites W1977248824 @default.
• W2024956957 cites W1978648995 @default.
• W2024956957 cites W1985106362 @default.
• W2024956957 cites W1985417601 @default.
• W2024956957 cites W1988325008 @default.
• W2024956957 cites W1992499163 @default.
• W2024956957 cites W1995117263 @default.
• W2024956957 cites W1999246687 @default.
• W2024956957 cites W2001155177 @default.
• W2024956957 cites W2024698877 @default.
• W2024956957 cites W2027835790 @default.
• W2024956957 cites W2028450100 @default.
• W2024956957 cites W2034069789 @default.
• W2024956957 cites W2042258271 @default.
• W2024956957 cites W2042303125 @default.
• W2024956957 cites W2044788861 @default.
• W2024956957 cites W2050819925 @default.
• W2024956957 cites W2053277833 @default.
• W2024956957 cites W2057443982 @default.
• W2024956957 cites W2068591703 @default.
• W2024956957 cites W2072463757 @default.
• W2024956957 cites W2078327597 @default.
• W2024956957 cites W2087772652 @default.
• W2024956957 cites W2089112219 @default.
• W2024956957 cites W2090476751 @default.
• W2024956957 cites W2159483368 @default.
• W2024956957 cites W2410587243 @default.
• W2024956957 cites W2622010354 @default.
• W2024956957 cites W4300918747 @default.
• W2024956957 doi "https://doi.org/10.1038/sj.bjp.0701265" @default.
• W2024956957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1564825" @default.
• W2024956957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9257920" @default.
• W2024956957 hasPublicationYear "1997" @default.
• W2024956957 type Work @default.
• W2024956957 sameAs 2024956957 @default.
• W2024956957 citedByCount "27" @default.
• W2024956957 countsByYear W20249569572015 @default.
• W2024956957 countsByYear W20249569572017 @default.
• W2024956957 crossrefType "journal-article" @default.
• W2024956957 hasAuthorship W2024956957A5004167898 @default.
• W2024956957 hasAuthorship W2024956957A5040421110 @default.
• W2024956957 hasAuthorship W2024956957A5044498093 @default.
• W2024956957 hasBestOaLocation W20249569572 @default.
• W2024956957 hasConcept C105702510 @default.
• W2024956957 hasConcept C118303440 @default.
• W2024956957 hasConcept C126322002 @default.
• W2024956957 hasConcept C141071460 @default.
• W2024956957 hasConcept C158846371 @default.
• W2024956957 hasConcept C163170386 @default.
• W2024956957 hasConcept C170493617 @default.
• W2024956957 hasConcept C2778096516 @default.
• W2024956957 hasConcept C2779753412 @default.
• W2024956957 hasConcept C2908736133 @default.
• W2024956957 hasConcept C71924100 @default.
• W2024956957 hasConceptScore W2024956957C105702510 @default.
• W2024956957 hasConceptScore W2024956957C118303440 @default.
• W2024956957 hasConceptScore W2024956957C126322002 @default.
• W2024956957 hasConceptScore W2024956957C141071460 @default.
• W2024956957 hasConceptScore W2024956957C158846371 @default.
• W2024956957 hasConceptScore W2024956957C163170386 @default.
• W2024956957 hasConceptScore W2024956957C170493617 @default.
• W2024956957 hasConceptScore W2024956957C2778096516 @default.
• W2024956957 hasConceptScore W2024956957C2779753412 @default.
• W2024956957 hasConceptScore W2024956957C2908736133 @default.
• W2024956957 hasConceptScore W2024956957C71924100 @default.
• W2024956957 hasLocation W20249569571 @default.
• W2024956957 hasLocation W20249569572 @default.
• W2024956957 hasLocation W20249569573 @default.
• W2024956957 hasLocation W20249569574 @default.
• W2024956957 hasOpenAccess W2024956957 @default.
• W2024956957 hasPrimaryLocation W20249569571 @default.
• W2024956957 hasRelatedWork W1966812088 @default.
• W2024956957 hasRelatedWork W2159676564 @default.
• W2024956957 hasRelatedWork W2255057375 @default.
• W2024956957 hasRelatedWork W2331968947 @default.
• W2024956957 hasRelatedWork W2337140056 @default.
• W2024956957 hasRelatedWork W2394106000 @default.
• W2024956957 hasRelatedWork W2914036817 @default.
• W2024956957 hasRelatedWork W3119617719 @default.
• W2024956957 hasRelatedWork W3122939982 @default.
• W2024956957 hasRelatedWork W3136031236 @default.
• W2024956957 isParatext "false" @default.
• W2024956957 isRetracted "false" @default.
• W2024956957 magId "2024956957" @default.
• W2024956957 workType "article" @default.