Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024957042> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2024957042 endingPage "250" @default.
- W2024957042 startingPage "247" @default.
- W2024957042 abstract "Objective. To examine the safety of the long acting β2-agonist, salmeterol, in general medical practice in the U.K. Design. In Prescription-Event Monitoring (PEM) the exposure data are derived from prescriptions confidentially provided by the Prescription Pricing Authority. Outcome data are obtained by questionnaires (green forms) on which prescribing medical practitioners recorded event (safety) data. Additional information is obtained from the patients' lifetime clinical records, from follow-up of all pregnancies, and from death certificates. Setting. PEM provides an observational cohort study in which there is no interference with the medical decision on which drug is prescribed for individual patients. Subjects. A total of 15,407 patients were given salmeterol and observed for a minimum of 1 year. Results. Headache, tremor, and palpitations were associated with the use of salmeterol. No unexpected major adverse events were noted, although in this study there was a total of 1022 deaths. Of these, 73 were due to asthma, but only 39 of these patients were taking salmeterol in the last month of life. All of these deaths appear on careful examination of the clinical records to have been due to natural causes, although in a minority (four, 10%) of the group of 39 subjects, a temporal relationship between death and the use of salmeterol makes it difficult to exclude a possible association. The study suggests that advanced age and severity of disease were the most likely factors contributing to asthma mortality in the population studied. Conclusion. Headache, tremor, and palpitations occur as adverse effects of salmeterol and lead to withdrawal of the drug in some subjects. No unexpected adverse reaction has been noted and paradoxical bronchospasm was reported in only three subjects. The study has produced no evidence that salmeterol contributed to death in any of the patients examined." @default.
- W2024957042 created "2016-06-24" @default.
- W2024957042 creator A5046117374 @default.
- W2024957042 creator A5055496519 @default.
- W2024957042 creator A5061841010 @default.
- W2024957042 creator A5077702002 @default.
- W2024957042 date "1996-02-01" @default.
- W2024957042 modified "2023-10-18" @default.
- W2024957042 title "Salmeterol: A study by Prescription Event Monitoring in a UK cohort of 15,407 patients" @default.
- W2024957042 cites W160493710 @default.
- W2024957042 cites W1968786861 @default.
- W2024957042 cites W1973869812 @default.
- W2024957042 cites W1984389609 @default.
- W2024957042 cites W1996720754 @default.
- W2024957042 cites W2000384099 @default.
- W2024957042 cites W2001483420 @default.
- W2024957042 cites W2007398946 @default.
- W2024957042 cites W2078636966 @default.
- W2024957042 cites W2085438091 @default.
- W2024957042 cites W2087666617 @default.
- W2024957042 cites W2092170492 @default.
- W2024957042 cites W2143625081 @default.
- W2024957042 cites W2152674193 @default.
- W2024957042 doi "https://doi.org/10.1016/0895-4356(95)00555-2" @default.
- W2024957042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8606326" @default.
- W2024957042 hasPublicationYear "1996" @default.
- W2024957042 type Work @default.
- W2024957042 sameAs 2024957042 @default.
- W2024957042 citedByCount "102" @default.
- W2024957042 countsByYear W20249570422012 @default.
- W2024957042 countsByYear W20249570422013 @default.
- W2024957042 countsByYear W20249570422014 @default.
- W2024957042 countsByYear W20249570422015 @default.
- W2024957042 countsByYear W20249570422016 @default.
- W2024957042 countsByYear W20249570422021 @default.
- W2024957042 countsByYear W20249570422022 @default.
- W2024957042 countsByYear W20249570422023 @default.
- W2024957042 crossrefType "journal-article" @default.
- W2024957042 hasAuthorship W2024957042A5046117374 @default.
- W2024957042 hasAuthorship W2024957042A5055496519 @default.
- W2024957042 hasAuthorship W2024957042A5061841010 @default.
- W2024957042 hasAuthorship W2024957042A5077702002 @default.
- W2024957042 hasConcept C126322002 @default.
- W2024957042 hasConcept C167135981 @default.
- W2024957042 hasConcept C194828623 @default.
- W2024957042 hasConcept C195910791 @default.
- W2024957042 hasConcept C197934379 @default.
- W2024957042 hasConcept C201903717 @default.
- W2024957042 hasConcept C23131810 @default.
- W2024957042 hasConcept C2426938 @default.
- W2024957042 hasConcept C2776042228 @default.
- W2024957042 hasConcept C2776403943 @default.
- W2024957042 hasConcept C2776719499 @default.
- W2024957042 hasConcept C2908647359 @default.
- W2024957042 hasConcept C71924100 @default.
- W2024957042 hasConcept C72563966 @default.
- W2024957042 hasConcept C98274493 @default.
- W2024957042 hasConcept C99454951 @default.
- W2024957042 hasConceptScore W2024957042C126322002 @default.
- W2024957042 hasConceptScore W2024957042C167135981 @default.
- W2024957042 hasConceptScore W2024957042C194828623 @default.
- W2024957042 hasConceptScore W2024957042C195910791 @default.
- W2024957042 hasConceptScore W2024957042C197934379 @default.
- W2024957042 hasConceptScore W2024957042C201903717 @default.
- W2024957042 hasConceptScore W2024957042C23131810 @default.
- W2024957042 hasConceptScore W2024957042C2426938 @default.
- W2024957042 hasConceptScore W2024957042C2776042228 @default.
- W2024957042 hasConceptScore W2024957042C2776403943 @default.
- W2024957042 hasConceptScore W2024957042C2776719499 @default.
- W2024957042 hasConceptScore W2024957042C2908647359 @default.
- W2024957042 hasConceptScore W2024957042C71924100 @default.
- W2024957042 hasConceptScore W2024957042C72563966 @default.
- W2024957042 hasConceptScore W2024957042C98274493 @default.
- W2024957042 hasConceptScore W2024957042C99454951 @default.
- W2024957042 hasIssue "2" @default.
- W2024957042 hasLocation W20249570421 @default.
- W2024957042 hasLocation W20249570422 @default.
- W2024957042 hasOpenAccess W2024957042 @default.
- W2024957042 hasPrimaryLocation W20249570421 @default.
- W2024957042 hasRelatedWork W1975622810 @default.
- W2024957042 hasRelatedWork W2117125885 @default.
- W2024957042 hasRelatedWork W2151598633 @default.
- W2024957042 hasRelatedWork W2153656683 @default.
- W2024957042 hasRelatedWork W2160823469 @default.
- W2024957042 hasRelatedWork W2602655960 @default.
- W2024957042 hasRelatedWork W2906373244 @default.
- W2024957042 hasRelatedWork W3009093370 @default.
- W2024957042 hasRelatedWork W45151993 @default.
- W2024957042 hasRelatedWork W2066105906 @default.
- W2024957042 hasVolume "49" @default.
- W2024957042 isParatext "false" @default.
- W2024957042 isRetracted "false" @default.
- W2024957042 magId "2024957042" @default.
- W2024957042 workType "article" @default.