FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024957780> ?p ?o ?g. }

• W2024957780 abstract "E7 proteins are major oncoproteins of human papillomaviruses (HPVs) which play a key role in virus-associated cervical carcinogenesis. The E7 oncoprotein of HPV-16 has been shown to interact with a variety of cellular target proteins and these interactions are considered essential for the transforming properties of this oncoprotein. Several additional HPV types associated etiologically to cervical cancer have been described, the second most common being HPV-18. Less is known about the biochemical functions and interactions of HPV-18 E7. As a first step to determine biochemical properties common to the E7 proteins of the high-risk HPV types 16 and 18 these E7 proteins were expressed in bacteria and purified to homogeneity. Purified E7 proteins were used to investigate the in vitro interaction with the pocket protein p107 and insulin-like growth factor-binding protein-3 (IGFBP-3) that are known to interact with the amino-terminal and the carboxyl-terminal part of IGFBP-3, respectively. Both purified E7 proteins interacted strongly with p107 and, as demonstrated here for the first time, HPV-18 E7 was capable of binding to IGFBP-3, albeit to a lesser extent than HPV-16 E7. These findings suggest that the purified recombinant E7 proteins retain, at least in part, their biochemical activities." @default.
• W2024957780 created "2016-06-24" @default.
• W2024957780 creator A5001620287 @default.
• W2024957780 creator A5007353087 @default.
• W2024957780 creator A5054629330 @default.
• W2024957780 creator A5076215352 @default.
• W2024957780 creator A5080305679 @default.
• W2024957780 creator A5085270734 @default.
• W2024957780 creator A5089852010 @default.
• W2024957780 date "2006-06-01" @default.
• W2024957780 modified "2023-10-18" @default.
• W2024957780 title "Purification and characterisation of the E7 oncoproteins of the high-risk human papillomavirus types 16 and 18" @default.
• W2024957780 cites W1503003173 @default.
• W2024957780 cites W1512653355 @default.
• W2024957780 cites W1538077572 @default.
• W2024957780 cites W1540314522 @default.
• W2024957780 cites W1544486735 @default.
• W2024957780 cites W1571709151 @default.
• W2024957780 cites W1574596120 @default.
• W2024957780 cites W1776463049 @default.
• W2024957780 cites W1831319429 @default.
• W2024957780 cites W1851271608 @default.
• W2024957780 cites W1975372808 @default.
• W2024957780 cites W1975522270 @default.
• W2024957780 cites W1975993749 @default.
• W2024957780 cites W2005517492 @default.
• W2024957780 cites W2006659499 @default.
• W2024957780 cites W2012505775 @default.
• W2024957780 cites W2028147924 @default.
• W2024957780 cites W2038500217 @default.
• W2024957780 cites W2039447573 @default.
• W2024957780 cites W2040115433 @default.
• W2024957780 cites W2056373000 @default.
• W2024957780 cites W2069104798 @default.
• W2024957780 cites W2077261304 @default.
• W2024957780 cites W2078066154 @default.
• W2024957780 cites W2098765233 @default.
• W2024957780 cites W2105272116 @default.
• W2024957780 cites W2112859230 @default.
• W2024957780 cites W2131900210 @default.
• W2024957780 cites W2137576859 @default.
• W2024957780 cites W2138461309 @default.
• W2024957780 cites W2141195019 @default.
• W2024957780 cites W2147186522 @default.
• W2024957780 cites W2158253659 @default.
• W2024957780 cites W2165399321 @default.
• W2024957780 cites W2179791758 @default.
• W2024957780 cites W22520275 @default.
• W2024957780 doi "https://doi.org/10.1016/j.jviromet.2005.11.014" @default.
• W2024957780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16384614" @default.
• W2024957780 hasPublicationYear "2006" @default.
• W2024957780 type Work @default.
• W2024957780 sameAs 2024957780 @default.
• W2024957780 citedByCount "11" @default.
• W2024957780 countsByYear W20249577802012 @default.
• W2024957780 countsByYear W20249577802013 @default.
• W2024957780 countsByYear W20249577802014 @default.
• W2024957780 countsByYear W20249577802016 @default.
• W2024957780 countsByYear W20249577802017 @default.
• W2024957780 crossrefType "journal-article" @default.
• W2024957780 hasAuthorship W2024957780A5001620287 @default.
• W2024957780 hasAuthorship W2024957780A5007353087 @default.
• W2024957780 hasAuthorship W2024957780A5054629330 @default.
• W2024957780 hasAuthorship W2024957780A5076215352 @default.
• W2024957780 hasAuthorship W2024957780A5080305679 @default.
• W2024957780 hasAuthorship W2024957780A5085270734 @default.
• W2024957780 hasAuthorship W2024957780A5089852010 @default.
• W2024957780 hasConcept C104317684 @default.
• W2024957780 hasConcept C121608353 @default.
• W2024957780 hasConcept C126322002 @default.
• W2024957780 hasConcept C153911025 @default.
• W2024957780 hasConcept C159047783 @default.
• W2024957780 hasConcept C165864922 @default.
• W2024957780 hasConcept C202751555 @default.
• W2024957780 hasConcept C2522874641 @default.
• W2024957780 hasConcept C2776270601 @default.
• W2024957780 hasConcept C2778220009 @default.
• W2024957780 hasConcept C2909762590 @default.
• W2024957780 hasConcept C2994532551 @default.
• W2024957780 hasConcept C40767141 @default.
• W2024957780 hasConcept C515207424 @default.
• W2024957780 hasConcept C54355233 @default.
• W2024957780 hasConcept C555283112 @default.
• W2024957780 hasConcept C71924100 @default.
• W2024957780 hasConcept C86339819 @default.
• W2024957780 hasConcept C86803240 @default.
• W2024957780 hasConcept C94966510 @default.
• W2024957780 hasConceptScore W2024957780C104317684 @default.
• W2024957780 hasConceptScore W2024957780C121608353 @default.
• W2024957780 hasConceptScore W2024957780C126322002 @default.
• W2024957780 hasConceptScore W2024957780C153911025 @default.
• W2024957780 hasConceptScore W2024957780C159047783 @default.
• W2024957780 hasConceptScore W2024957780C165864922 @default.
• W2024957780 hasConceptScore W2024957780C202751555 @default.
• W2024957780 hasConceptScore W2024957780C2522874641 @default.
• W2024957780 hasConceptScore W2024957780C2776270601 @default.
• W2024957780 hasConceptScore W2024957780C2778220009 @default.
• W2024957780 hasConceptScore W2024957780C2909762590 @default.
• W2024957780 hasConceptScore W2024957780C2994532551 @default.
• W2024957780 hasConceptScore W2024957780C40767141 @default.

• next