Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024960053> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2024960053 endingPage "pe10" @default.
- W2024960053 startingPage "pe10" @default.
- W2024960053 abstract "For one hundred years after Alois Alzheimer's first report of Alzheimer's disease (AD) in 1906, the pathological hallmarks of the disease, senile plaques and neurofibrillary tangles (NFTs), have been attractive targets for researchers. Therefore, not surprisingly, efforts to understand disease mechanisms have concentrated on the cell biology of amyloid-beta (Abeta) deposition as senile plaques or on the phosphorylation and aggregation of tau as NFTs. However, it now appears that this focus on pathology as a central contributor to disease may be misguided. Indeed, neurons associated with Abeta and NFTs in AD brain show a decrease in oxidative damage relative to those in vulnerable but morphologically intact areas of the brain, suggesting that neurodegenerative lesions are compensatory phenomena, and thus manifestations of cellular adaptation. That Abeta and tau accumulations indicate an age-related physiological reaction to chronic stress calls into question the rationale of current therapeutic efforts targeted toward lesion removal. Moreover, if this concept holds true for pathology in other neurodegenerative diseases, we may need to restructure our thinking and undergo a paradigm shift before substantial progress can be made in therapeutic intervention." @default.
- W2024960053 created "2016-06-24" @default.
- W2024960053 creator A5008252393 @default.
- W2024960053 creator A5012826249 @default.
- W2024960053 creator A5015712517 @default.
- W2024960053 creator A5021420538 @default.
- W2024960053 creator A5053059798 @default.
- W2024960053 creator A5071772212 @default.
- W2024960053 creator A5075477128 @default.
- W2024960053 date "2006-05-03" @default.
- W2024960053 modified "2023-09-27" @default.
- W2024960053 title "Neuropathology in Alzheimer's Disease: Awaking from a Hundred-Year-Old Dream" @default.
- W2024960053 doi "https://doi.org/10.1126/sageke.2006.8.pe10" @default.
- W2024960053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16672726" @default.
- W2024960053 hasPublicationYear "2006" @default.
- W2024960053 type Work @default.
- W2024960053 sameAs 2024960053 @default.
- W2024960053 citedByCount "7" @default.
- W2024960053 countsByYear W20249600532013 @default.
- W2024960053 countsByYear W20249600532014 @default.
- W2024960053 countsByYear W20249600532015 @default.
- W2024960053 countsByYear W20249600532017 @default.
- W2024960053 countsByYear W20249600532019 @default.
- W2024960053 crossrefType "journal-article" @default.
- W2024960053 hasAuthorship W2024960053A5008252393 @default.
- W2024960053 hasAuthorship W2024960053A5012826249 @default.
- W2024960053 hasAuthorship W2024960053A5015712517 @default.
- W2024960053 hasAuthorship W2024960053A5021420538 @default.
- W2024960053 hasAuthorship W2024960053A5053059798 @default.
- W2024960053 hasAuthorship W2024960053A5071772212 @default.
- W2024960053 hasAuthorship W2024960053A5075477128 @default.
- W2024960053 hasConcept C11171543 @default.
- W2024960053 hasConcept C126322002 @default.
- W2024960053 hasConcept C15744967 @default.
- W2024960053 hasConcept C169760540 @default.
- W2024960053 hasConcept C2779134260 @default.
- W2024960053 hasConcept C2780130745 @default.
- W2024960053 hasConcept C2781095916 @default.
- W2024960053 hasConcept C71924100 @default.
- W2024960053 hasConcept C74909509 @default.
- W2024960053 hasConceptScore W2024960053C11171543 @default.
- W2024960053 hasConceptScore W2024960053C126322002 @default.
- W2024960053 hasConceptScore W2024960053C15744967 @default.
- W2024960053 hasConceptScore W2024960053C169760540 @default.
- W2024960053 hasConceptScore W2024960053C2779134260 @default.
- W2024960053 hasConceptScore W2024960053C2780130745 @default.
- W2024960053 hasConceptScore W2024960053C2781095916 @default.
- W2024960053 hasConceptScore W2024960053C71924100 @default.
- W2024960053 hasConceptScore W2024960053C74909509 @default.
- W2024960053 hasIssue "8" @default.
- W2024960053 hasLocation W20249600531 @default.
- W2024960053 hasLocation W20249600532 @default.
- W2024960053 hasOpenAccess W2024960053 @default.
- W2024960053 hasPrimaryLocation W20249600531 @default.
- W2024960053 hasRelatedWork W1786300992 @default.
- W2024960053 hasRelatedWork W1993598577 @default.
- W2024960053 hasRelatedWork W2065382820 @default.
- W2024960053 hasRelatedWork W2069459097 @default.
- W2024960053 hasRelatedWork W2070008559 @default.
- W2024960053 hasRelatedWork W2133936860 @default.
- W2024960053 hasRelatedWork W2386985152 @default.
- W2024960053 hasRelatedWork W2410992372 @default.
- W2024960053 hasRelatedWork W2418579776 @default.
- W2024960053 hasRelatedWork W2460434225 @default.
- W2024960053 hasVolume "2006" @default.
- W2024960053 isParatext "false" @default.
- W2024960053 isRetracted "false" @default.
- W2024960053 magId "2024960053" @default.
- W2024960053 workType "article" @default.