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- W2024961631 abstract "One postulated mechanism for how the SV40 enhancer stimulates transcription of linked genes involves the enhancer as a binding site for a sequence-specific “gyrase” activity. We sought to test this hypothesis directly by constructing a novel heteroduplex circle, termed a tailed-circle, in which one of the strands contains an extra palindromic sequence base-paired into a hairpin structure. The human β-globin gene is placed in the circle and the SV40 enhancer on the hairpin tail, where a bound topoisomerase cannot supercoil the circle. Upon transfection of this DNA into HeLa cells the SV40 enhancer on the hairpin arm is still able to stimulate transcription of the β-globin gene. Southern blot analysis of the DNA after transfection does not demonstrate any repair or replication of the tailed-circle in vivo. These results argue against the sequence-specific gyrase model for SV40 enhancer action." @default.
- W2024961631 created "2016-06-24" @default.
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- W2024961631 date "1986-05-01" @default.
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- W2024961631 title "Transcription of the human β-globin gene is stimulated by an SV40 enhancer to which it is physically linked but topologically uncoupled" @default.
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- W2024961631 doi "https://doi.org/10.1016/0092-8674(86)90289-8" @default.
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