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• W2024962078 abstract "A cDNA clone designated NGB, which was isolated from a rat brain expression library, detected two mRNA species of 1.8 and 4.0 kb which are highly enriched in brain tissue. cDNAs NGB1 and NGB2 corresponding to these two mRNAs have been isolated and characterized. Sequence data showed that both mRNA species contain the same open reading frames but differ in their 3' untranslated regions. The open reading frame encodes a calmodulin protein of 148 amino acids. Both mRNA species are derived from the rat CaMI gene by utilization of different polyadenylation addition sites. Analysis of the 3' untranslated sequence which is unique to the larger mRNA species revealed a putative AU-rich 'destabilizer' sequence which is thought to be involved in mechanisms of selective mRNA breakdown. In situ hybridization studies revealed that the two calmodulin mRNAs are expressed strongly in neuronal cells in the adult rat brain. Levels of the two mRNA species increased during early postnatal development." @default.
• W2024962078 created "2016-06-24" @default.
• W2024962078 creator A5027841522 @default.
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• W2024962078 date "1992-03-01" @default.
• W2024962078 modified "2023-09-23" @default.
• W2024962078 title "Molecular cloning of calmodulin mRNA species which are preferentially expressed in neurons in the rat brain" @default.
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• W2024962078 doi "https://doi.org/10.1016/0169-328x(92)90039-e" @default.
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