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- W2024962884 abstract "Roots of Vicia faba were treated with 5-fluorodeoxyuridine (FUdR) for 3 hr. This compound has been used as a selective inhibitor of DNA synthesis but evidence is presented that it also arrests cells in G 2 and prevents them from progressing to mitosis. Even with 10 −7 M solutions, inhibition is evident by 2 hr. The blockage of G 2 cells occurs both in cells with a G 2 of long duration (> 12 hr) and short duration (3.3 hr). The result is that any estimate of the duration of G 2 in cells treated with FUdR is an underestimate. It appears that treated cells have a shorter G 2 than have untreated cells but, in fact, it has been considerably extended. It is unclear why a compound that supposedly specifically inhibits DNA synthesis, by preventing the formation of thymidylic acid, should arrest cells that have already completed DNA synthesis and are in the G 2 phase of the mitotic cycle." @default.
- W2024962884 created "2016-06-24" @default.
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- W2024962884 date "1971-03-01" @default.
- W2024962884 modified "2023-10-16" @default.
- W2024962884 title "EVIDENCE FOR AN EFFECT OF 5-FLUORODEOXYURIDINE ON CELLS IN THE G2 PHASE OF THE MITOTIC CYCLE" @default.
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- W2024962884 doi "https://doi.org/10.1139/g71-010" @default.
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