Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024963046> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2024963046 endingPage "1195" @default.
- W2024963046 startingPage "1192" @default.
- W2024963046 abstract "1 5-Hydroxytryptamine (5-HT), in the presence of propranolol (1 μm), atropine (3 μm) and ketanserin (1 μm), induced a positive inotropic response of guinea-pig isolated electrically paced left atria (pEC50 = 7.52). The positive inotropic response was mimicked by α-methyl-5-HT (pEC50 = 7.26) and 5-carboxamidotryptamine (5-CT; pEC50 = 6.56) but not by sumatriptan or 1-(m-chlorophenyl) piperazine (m-CPP). 2 The 5-HT induced positive inotropic response was competitively antagonized by both mesulergine (pA2 = 7.68) and methiothepin (pA2 = 6.67). Methysergide was a surmountable antagonist at 3 nm producing a rightward shift in the 5-HT concentration-response curve giving an apparent pA2 = 9.2 with no significant reduction in the maximum. At higher concentrations, methysergide behaved as an insurmountable antagonist, significantly reducing the maximum response to 5-HT as well as producing rightward shifts in the 5-HT concentration-response curves. 3 The 5-HT-induced positive inotropic response was not antagonized by either tropisetron (10 μm) or yohimbine (10 μm). 4 The guinea-pig atrial 5-HT receptor does not satisfy the criteria for any of the currently recognised 5-HT receptor subtypes and appears to have some similarities to the atypical 5-HT receptors previously described in other peripheral tissues." @default.
- W2024963046 created "2016-06-24" @default.
- W2024963046 creator A5007127021 @default.
- W2024963046 creator A5030239271 @default.
- W2024963046 creator A5066743145 @default.
- W2024963046 date "1993-08-01" @default.
- W2024963046 modified "2023-09-26" @default.
- W2024963046 title "Characterization of the 5-hydroxytryptamine receptor mediating the positive inotropic response in guinea-pig isolated left atria" @default.
- W2024963046 cites W1936333617 @default.
- W2024963046 cites W1969168512 @default.
- W2024963046 cites W1971486356 @default.
- W2024963046 cites W1973270461 @default.
- W2024963046 cites W1983664314 @default.
- W2024963046 cites W1987323999 @default.
- W2024963046 cites W1998615691 @default.
- W2024963046 cites W2004113689 @default.
- W2024963046 cites W2005395166 @default.
- W2024963046 cites W2009164474 @default.
- W2024963046 cites W2022089536 @default.
- W2024963046 cites W2057971042 @default.
- W2024963046 cites W2090064865 @default.
- W2024963046 cites W2128874542 @default.
- W2024963046 cites W2137857262 @default.
- W2024963046 cites W2152270304 @default.
- W2024963046 cites W2292558343 @default.
- W2024963046 cites W2414081636 @default.
- W2024963046 cites W2996307228 @default.
- W2024963046 cites W4290301873 @default.
- W2024963046 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13748.x" @default.
- W2024963046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175719" @default.
- W2024963046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8401929" @default.
- W2024963046 hasPublicationYear "1993" @default.
- W2024963046 type Work @default.
- W2024963046 sameAs 2024963046 @default.
- W2024963046 citedByCount "5" @default.
- W2024963046 crossrefType "journal-article" @default.
- W2024963046 hasAuthorship W2024963046A5007127021 @default.
- W2024963046 hasAuthorship W2024963046A5030239271 @default.
- W2024963046 hasAuthorship W2024963046A5066743145 @default.
- W2024963046 hasBestOaLocation W20249630462 @default.
- W2024963046 hasConcept C126322002 @default.
- W2024963046 hasConcept C134018914 @default.
- W2024963046 hasConcept C155710745 @default.
- W2024963046 hasConcept C170493617 @default.
- W2024963046 hasConcept C185592680 @default.
- W2024963046 hasConcept C2775864247 @default.
- W2024963046 hasConcept C2776885963 @default.
- W2024963046 hasConcept C2777676773 @default.
- W2024963046 hasConcept C2777785214 @default.
- W2024963046 hasConcept C2778122271 @default.
- W2024963046 hasConcept C2778151854 @default.
- W2024963046 hasConcept C2781005078 @default.
- W2024963046 hasConcept C53910766 @default.
- W2024963046 hasConcept C71924100 @default.
- W2024963046 hasConcept C98274493 @default.
- W2024963046 hasConceptScore W2024963046C126322002 @default.
- W2024963046 hasConceptScore W2024963046C134018914 @default.
- W2024963046 hasConceptScore W2024963046C155710745 @default.
- W2024963046 hasConceptScore W2024963046C170493617 @default.
- W2024963046 hasConceptScore W2024963046C185592680 @default.
- W2024963046 hasConceptScore W2024963046C2775864247 @default.
- W2024963046 hasConceptScore W2024963046C2776885963 @default.
- W2024963046 hasConceptScore W2024963046C2777676773 @default.
- W2024963046 hasConceptScore W2024963046C2777785214 @default.
- W2024963046 hasConceptScore W2024963046C2778122271 @default.
- W2024963046 hasConceptScore W2024963046C2778151854 @default.
- W2024963046 hasConceptScore W2024963046C2781005078 @default.
- W2024963046 hasConceptScore W2024963046C53910766 @default.
- W2024963046 hasConceptScore W2024963046C71924100 @default.
- W2024963046 hasConceptScore W2024963046C98274493 @default.
- W2024963046 hasIssue "4" @default.
- W2024963046 hasLocation W20249630461 @default.
- W2024963046 hasLocation W20249630462 @default.
- W2024963046 hasLocation W20249630463 @default.
- W2024963046 hasLocation W20249630464 @default.
- W2024963046 hasOpenAccess W2024963046 @default.
- W2024963046 hasPrimaryLocation W20249630461 @default.
- W2024963046 hasRelatedWork W1785185999 @default.
- W2024963046 hasRelatedWork W1970213404 @default.
- W2024963046 hasRelatedWork W1984486327 @default.
- W2024963046 hasRelatedWork W1991383116 @default.
- W2024963046 hasRelatedWork W2009619957 @default.
- W2024963046 hasRelatedWork W2024963046 @default.
- W2024963046 hasRelatedWork W2054184534 @default.
- W2024963046 hasRelatedWork W2080546926 @default.
- W2024963046 hasRelatedWork W2082550582 @default.
- W2024963046 hasRelatedWork W2088064608 @default.
- W2024963046 hasVolume "109" @default.
- W2024963046 isParatext "false" @default.
- W2024963046 isRetracted "false" @default.
- W2024963046 magId "2024963046" @default.
- W2024963046 workType "article" @default.