Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024964547> ?p ?o ?g. }
- W2024964547 endingPage "144" @default.
- W2024964547 startingPage "138" @default.
- W2024964547 abstract "Object. In this study the authors compared the effects of both a selective inducible nitric oxide synthase (iNOS) inhibitor and a nonselective inhibitor on posttraumatic recovery and neuron survival by using a combined model of lateral fluid percussion injury (FPI) and hemorrhagic shock (HS). Methods. Male Sprague—Dawley rats weighing 300 to 350 g underwent FPI to the brain (3.5 atm) and hemorrhage to a mean arterial blood pressure (MABP) of 40 mm Hg for 1 hour. Rats were then resuscitated during 1 hour with bolus infusions of aminoguanidine (AG) or nitro- l -arginine methyl ester ( l -NAME). Neuronal apoptosis was determined by performing Nissl staining and in situ terminal deoxynucleotidyl transferase—mediated deoxyuridine triphosphate nick-end labeling technique. Rats infused with AG showed a significant increase in mean survival time and cerebral tissue perfusion, although the MABP and nitrate/nitrite levels did not significantly change compared with those in l -NAME—treated rats even though both animal groups had been subjected to combined FPI and HS, FPI alone, or HS alone. Furthermore, infusion of AG also significantly decreased the number of apoptotic neurons when compared with the number in rats treated with l -NAME. Conclusions. The authors asserted that treatment with AG, which causes the inhibition of iNOS, might contribute to improved physiological parameters and neuronal cell survival following FPI and HS." @default.
- W2024964547 created "2016-06-24" @default.
- W2024964547 creator A5006830309 @default.
- W2024964547 creator A5012798032 @default.
- W2024964547 creator A5014693062 @default.
- W2024964547 creator A5032198372 @default.
- W2024964547 creator A5037981698 @default.
- W2024964547 creator A5043641656 @default.
- W2024964547 date "2004-07-01" @default.
- W2024964547 modified "2023-09-26" @default.
- W2024964547 title "Effects of aminoguanidine and l-arginine methyl ester resuscitation following induction of fluid percussion injury and severe controlled hemorrhagic shock in the rat brain" @default.
- W2024964547 cites W1964512080 @default.
- W2024964547 cites W1968772061 @default.
- W2024964547 cites W1970219277 @default.
- W2024964547 cites W1973445440 @default.
- W2024964547 cites W1973671786 @default.
- W2024964547 cites W1977077322 @default.
- W2024964547 cites W1980895604 @default.
- W2024964547 cites W1983768020 @default.
- W2024964547 cites W1991034717 @default.
- W2024964547 cites W1999845986 @default.
- W2024964547 cites W2000832826 @default.
- W2024964547 cites W2002984543 @default.
- W2024964547 cites W2008908894 @default.
- W2024964547 cites W2026720834 @default.
- W2024964547 cites W2031813159 @default.
- W2024964547 cites W2036446038 @default.
- W2024964547 cites W2040820190 @default.
- W2024964547 cites W2044571191 @default.
- W2024964547 cites W2046331318 @default.
- W2024964547 cites W2047910756 @default.
- W2024964547 cites W2051786023 @default.
- W2024964547 cites W2058096069 @default.
- W2024964547 cites W2067798673 @default.
- W2024964547 cites W2077754887 @default.
- W2024964547 cites W2083601339 @default.
- W2024964547 cites W2087690555 @default.
- W2024964547 cites W2094188444 @default.
- W2024964547 cites W2127509282 @default.
- W2024964547 cites W2161908936 @default.
- W2024964547 cites W3158470188 @default.
- W2024964547 cites W4246590546 @default.
- W2024964547 doi "https://doi.org/10.3171/jns.2004.101.1.0138" @default.
- W2024964547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15255264" @default.
- W2024964547 hasPublicationYear "2004" @default.
- W2024964547 type Work @default.
- W2024964547 sameAs 2024964547 @default.
- W2024964547 citedByCount "3" @default.
- W2024964547 crossrefType "journal-article" @default.
- W2024964547 hasAuthorship W2024964547A5006830309 @default.
- W2024964547 hasAuthorship W2024964547A5012798032 @default.
- W2024964547 hasAuthorship W2024964547A5014693062 @default.
- W2024964547 hasAuthorship W2024964547A5032198372 @default.
- W2024964547 hasAuthorship W2024964547A5037981698 @default.
- W2024964547 hasAuthorship W2024964547A5043641656 @default.
- W2024964547 hasConcept C126322002 @default.
- W2024964547 hasConcept C134018914 @default.
- W2024964547 hasConcept C142724271 @default.
- W2024964547 hasConcept C185592680 @default.
- W2024964547 hasConcept C190283241 @default.
- W2024964547 hasConcept C196795494 @default.
- W2024964547 hasConcept C204232928 @default.
- W2024964547 hasConcept C2777468819 @default.
- W2024964547 hasConcept C2777622882 @default.
- W2024964547 hasConcept C2778165595 @default.
- W2024964547 hasConcept C2781300812 @default.
- W2024964547 hasConcept C37753355 @default.
- W2024964547 hasConcept C42219234 @default.
- W2024964547 hasConcept C43376680 @default.
- W2024964547 hasConcept C515207424 @default.
- W2024964547 hasConcept C519581460 @default.
- W2024964547 hasConcept C55493867 @default.
- W2024964547 hasConcept C71924100 @default.
- W2024964547 hasConcept C74864618 @default.
- W2024964547 hasConceptScore W2024964547C126322002 @default.
- W2024964547 hasConceptScore W2024964547C134018914 @default.
- W2024964547 hasConceptScore W2024964547C142724271 @default.
- W2024964547 hasConceptScore W2024964547C185592680 @default.
- W2024964547 hasConceptScore W2024964547C190283241 @default.
- W2024964547 hasConceptScore W2024964547C196795494 @default.
- W2024964547 hasConceptScore W2024964547C204232928 @default.
- W2024964547 hasConceptScore W2024964547C2777468819 @default.
- W2024964547 hasConceptScore W2024964547C2777622882 @default.
- W2024964547 hasConceptScore W2024964547C2778165595 @default.
- W2024964547 hasConceptScore W2024964547C2781300812 @default.
- W2024964547 hasConceptScore W2024964547C37753355 @default.
- W2024964547 hasConceptScore W2024964547C42219234 @default.
- W2024964547 hasConceptScore W2024964547C43376680 @default.
- W2024964547 hasConceptScore W2024964547C515207424 @default.
- W2024964547 hasConceptScore W2024964547C519581460 @default.
- W2024964547 hasConceptScore W2024964547C55493867 @default.
- W2024964547 hasConceptScore W2024964547C71924100 @default.
- W2024964547 hasConceptScore W2024964547C74864618 @default.
- W2024964547 hasIssue "1" @default.
- W2024964547 hasLocation W20249645471 @default.
- W2024964547 hasLocation W20249645472 @default.
- W2024964547 hasOpenAccess W2024964547 @default.
- W2024964547 hasPrimaryLocation W20249645471 @default.