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• W2024965773 abstract "Future Medicinal ChemistryVol. 6, No. 7 EditorialModeling hepatic drug metabolism and toxicity: where are we heading?Dominic P WilliamsDominic P WilliamsSearch for more papers by this authorPublished Online:19 Jun 2014https://doi.org/10.4155/fmc.14.31AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: bioreactordrug safetyhepatichepatotoxicitylivermetabolismmicrotissuetoxicityReferences1 Pirmohamed M, James S, Meakin S et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ 329(7456), 15–19 (2004).Crossref, Medline, Google Scholar2 Davies EC, Green CF, Taylor S, Williamson PR, Mottram DR, Pirmohamed M. Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS ONE 4(2), e4439 (2009).Crossref, Medline, Google Scholar3 Boseley S. Adverse drug reactions cost NHS £2 billion. www.theguardian.com/society/2008/apr/03/nhs.drugsandalcohol Google Scholar4 Thomas S. Physiologically-based pharmacokinetic modelling for the reduction of animal use in the discovery of novel pharmaceuticals. Altern. Lab. Anim. 38(Suppl. 1), 81–85 (2010).Crossref, Medline, CAS, Google Scholar5 Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3(8), 711–715 (2004).Crossref, Medline, CAS, Google Scholar6 Nibourg GA, Chamuleau RA, van Gulik TM, Hoekstra R. Proliferative human cell sources applied as biocomponent in bioartificial livers: a review. Expert Opin. Biol. Ther. 12(7), 905–921 (2012).Crossref, Medline, CAS, Google Scholar7 Schulz S, Schmitt S, Wimmer R et al. Progressive stages of mitochondrial destruction caused by cell toxic bile salts. Biochim. Biophys. Acta 1828(9), 2121–2133 (2013).Crossref, Medline, CAS, Google Scholar8 Davidson AJ, Ellis MJ, Chaudhuri JB. A theoretical method to improve and optimize the design of bioartificial livers. Biotechnol. Bioeng. 106(6), 980–988 (2010).Crossref, Medline, CAS, Google Scholar9 Davidson AJ, Ellis MJ, Chaudhuri JB. A theoretical approach to zonation in a bioartificial liver. Biotechnol. Bioeng. 109(1), 234–243 (2012).Crossref, Medline, CAS, Google Scholar10 Allen JW, Bhatia SN. Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol. Bioeng. 82(3), 253–262 (2003).Crossref, Medline, CAS, Google Scholar11 Allen JW, Khetani SR, Bhatia SN. In vitro zonation and toxicity in a hepatocyte bioreactor. Toxicol. Sci. 84(1), 110–119 (2005).Crossref, Medline, CAS, Google Scholar12 Messner S, Agarkova I, Moritz W, Kelm JM. Multi-cell type human liver microtissues for hepatotoxicity testing. Arch. Toxicol. 87(1), 209–213 (2013).Crossref, Medline, CAS, Google Scholar13 Ramm S, Mally A. Role of drug-independent stress factors in liver injury associated with diclofenac intake. Toxicology 312, 83–96 (2013).Crossref, Medline, CAS, Google Scholar14 March S, Hui EE, Underhill GH, Khetani S, Bhatia SN. Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology 50(3), 920–928 (2009).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByA Comprehensive Overview of the Current Status and Application of Predictive ADMET: Introduction and Overview Vol. 6, No. 7 Follow us on social media for the latest updates Metrics Downloaded 59 times History Published online 19 June 2014 Published in print May 2014 Information© Future Science LtdKeywordsbioreactordrug safetyhepatichepatotoxicitylivermetabolismmicrotissuetoxicityFinancial & competing interests disclosureThe author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert t­estimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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