FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024968909> ?p ?o ?g. }

• W2024968909 endingPage "e42736" @default.
• W2024968909 startingPage "e42736" @default.
• W2024968909 abstract "Mortality associated with invasive aspergillosis (IA) remains high, partly because of delayed diagnosis. Detection of microbial exoantigens, released in serum and other body fluids during infection, may help timely diagnosis. In course of IA, Aspergillus galactomannan (GM), a well established polysaccharide biomarker, is released in body fluids including urine. Urine is an abundant, safely collected specimen, well-suited for point-of-care (POC) testing, which could play an increasing role in screening for early disease. Our main objective was to demonstrate GM antigenuria as a clinically relevant biological phenomenon in IA and establish proof-of-concept that it could be translated to POC diagnosis. Utilizing a novel IgM monoclonal antibody (MAb476) that recognizes GM-like antigens from Aspergillus and other molds, we demonstrated antigenuria in an experimental animal IA model (guinea pig), as well as in human patients. In addition, we investigated the chemical nature of the urinary excreted antigen in human samples, characterized antigen detection in urine by immunoassays, described a putative assay inhibitor in urine, and indicated means of alleviation of the inhibition. We also designed and used a lateral flow immunochromatographic assay to detect urinary excreted antigen in a limited number of IA patient urine samples. In this study, we establish that POC diagnosis of IA based on urinary GM detection is feasible. Prospective studies will be necessary to establish the performance characteristics of an optimized device and define its optimal clinical use." @default.
• W2024968909 created "2016-06-24" @default.
• W2024968909 creator A5021310794 @default.
• W2024968909 creator A5034610205 @default.
• W2024968909 creator A5043440739 @default.
• W2024968909 creator A5050576085 @default.
• W2024968909 creator A5067942412 @default.
• W2024968909 creator A5077065723 @default.
• W2024968909 creator A5080425175 @default.
• W2024968909 creator A5089106850 @default.
• W2024968909 date "2012-08-10" @default.
• W2024968909 modified "2023-10-08" @default.
• W2024968909 title "Detection of Urinary Excreted Fungal Galactomannan-like Antigens for Diagnosis of Invasive Aspergillosis" @default.
• W2024968909 cites W1516462031 @default.
• W2024968909 cites W1538685542 @default.
• W2024968909 cites W1568021747 @default.
• W2024968909 cites W1827225384 @default.
• W2024968909 cites W1909891465 @default.
• W2024968909 cites W1915036617 @default.
• W2024968909 cites W1931368951 @default.
• W2024968909 cites W1981409181 @default.
• W2024968909 cites W1987887957 @default.
• W2024968909 cites W1989811002 @default.
• W2024968909 cites W1991133375 @default.
• W2024968909 cites W1994296907 @default.
• W2024968909 cites W2012386851 @default.
• W2024968909 cites W2019391534 @default.
• W2024968909 cites W2022089921 @default.
• W2024968909 cites W2024710521 @default.
• W2024968909 cites W2031406182 @default.
• W2024968909 cites W2032938607 @default.
• W2024968909 cites W2054018847 @default.
• W2024968909 cites W2068768342 @default.
• W2024968909 cites W2082541869 @default.
• W2024968909 cites W2095837810 @default.
• W2024968909 cites W2097490387 @default.
• W2024968909 cites W2102237555 @default.
• W2024968909 cites W2102962593 @default.
• W2024968909 cites W2107704185 @default.
• W2024968909 cites W2112021210 @default.
• W2024968909 cites W2114872234 @default.
• W2024968909 cites W2120189372 @default.
• W2024968909 cites W2121211481 @default.
• W2024968909 cites W2121822883 @default.
• W2024968909 cites W2123332089 @default.
• W2024968909 cites W2128039798 @default.
• W2024968909 cites W2133167433 @default.
• W2024968909 cites W2138992291 @default.
• W2024968909 cites W2139678747 @default.
• W2024968909 cites W2141282012 @default.
• W2024968909 cites W2146306688 @default.
• W2024968909 cites W2147055465 @default.
• W2024968909 cites W2151213532 @default.
• W2024968909 cites W2151673476 @default.
• W2024968909 cites W2153096447 @default.
• W2024968909 cites W2153911335 @default.
• W2024968909 cites W2154960522 @default.
• W2024968909 cites W2155736066 @default.
• W2024968909 cites W2156924221 @default.
• W2024968909 cites W2158672061 @default.
• W2024968909 cites W2166734004 @default.
• W2024968909 cites W2170230158 @default.
• W2024968909 cites W2171894547 @default.
• W2024968909 cites W22399641 @default.
• W2024968909 cites W2565410782 @default.
• W2024968909 cites W3023760018 @default.
• W2024968909 doi "https://doi.org/10.1371/journal.pone.0042736" @default.
• W2024968909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3416763" @default.
• W2024968909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22900046" @default.
• W2024968909 hasPublicationYear "2012" @default.
• W2024968909 type Work @default.
• W2024968909 sameAs 2024968909 @default.
• W2024968909 citedByCount "52" @default.
• W2024968909 countsByYear W20249689092012 @default.
• W2024968909 countsByYear W20249689092013 @default.
• W2024968909 countsByYear W20249689092014 @default.
• W2024968909 countsByYear W20249689092015 @default.
• W2024968909 countsByYear W20249689092016 @default.
• W2024968909 countsByYear W20249689092017 @default.
• W2024968909 countsByYear W20249689092018 @default.
• W2024968909 countsByYear W20249689092019 @default.
• W2024968909 countsByYear W20249689092020 @default.
• W2024968909 countsByYear W20249689092021 @default.
• W2024968909 countsByYear W20249689092022 @default.
• W2024968909 countsByYear W20249689092023 @default.
• W2024968909 crossrefType "journal-article" @default.
• W2024968909 hasAuthorship W2024968909A5021310794 @default.
• W2024968909 hasAuthorship W2024968909A5034610205 @default.
• W2024968909 hasAuthorship W2024968909A5043440739 @default.
• W2024968909 hasAuthorship W2024968909A5050576085 @default.
• W2024968909 hasAuthorship W2024968909A5067942412 @default.
• W2024968909 hasAuthorship W2024968909A5077065723 @default.
• W2024968909 hasAuthorship W2024968909A5080425175 @default.
• W2024968909 hasAuthorship W2024968909A5089106850 @default.
• W2024968909 hasBestOaLocation W20249689091 @default.
• W2024968909 hasConcept C126322002 @default.
• W2024968909 hasConcept C142724271 @default.
• W2024968909 hasConcept C147483822 @default.

• next