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- W2024968963 endingPage "328" @default.
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- W2024968963 abstract "The highly conserved homeodomains and HMG domains are components of a large number of proteins that play a role in the transcriptional regulation of gene expression during embryogenesis. Both the HMG domain and the homeodomain serve as interfaces for factor interactions with DNA, as well as with other proteins, and it is likely that the high degree of structural and sequence conservation within these domains reflects the conservation of basic aspects of these interactions. Classical HMG domain proteins have an ancient origin, being found in all eukaryotes, and are thought to have given rise to the metazoan-specific class of HMG domain proteins called the Sox proteins. Similarly, the metazoan-specific POU domain proteins are thought to have arisen from genes encoding ancestral homeodomain proteins. In this review, we summarize several examples of different HMG-homeodomain interactions that illustrate not only the ancient origin of each of these protein families, but also their relationship to each other, and discuss how coevolution of HMG and homeodomains may have lead to creation of the specialized Sox/POU protein complexes. Using the FGF-4 gene as an example, we also speculate on how coevolution of regulatory Sox/POU target DNA sequences may have occurred, and how the summation of these changes may have lead to the emergence of new developmental pathways." @default.
- W2024968963 created "2016-06-24" @default.
- W2024968963 creator A5015845099 @default.
- W2024968963 creator A5091002644 @default.
- W2024968963 date "2001-01-01" @default.
- W2024968963 modified "2023-10-18" @default.
- W2024968963 title "Coevolution of HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes" @default.
- W2024968963 cites W1489505384 @default.
- W2024968963 cites W1519947104 @default.
- W2024968963 cites W1524615273 @default.
- W2024968963 cites W1570696801 @default.
- W2024968963 cites W1584850257 @default.
- W2024968963 cites W1608762409 @default.
- W2024968963 cites W1632044028 @default.
- W2024968963 cites W1773515121 @default.
- W2024968963 cites W1827567296 @default.
- W2024968963 cites W1833742808 @default.
- W2024968963 cites W1863806217 @default.
- W2024968963 cites W1889979414 @default.
- W2024968963 cites W1935354242 @default.
- W2024968963 cites W1951882906 @default.
- W2024968963 cites W1955411410 @default.
- W2024968963 cites W1958675029 @default.
- W2024968963 cites W1969005524 @default.
- W2024968963 cites W1969801859 @default.
- W2024968963 cites W1973295687 @default.
- W2024968963 cites W1975211058 @default.
- W2024968963 cites W1979423222 @default.
- W2024968963 cites W1979981202 @default.
- W2024968963 cites W1980147031 @default.
- W2024968963 cites W1981088384 @default.
- W2024968963 cites W1985360296 @default.
- W2024968963 cites W1987390450 @default.
- W2024968963 cites W1990097058 @default.
- W2024968963 cites W1990230630 @default.
- W2024968963 cites W1992994796 @default.
- W2024968963 cites W1999131239 @default.
- W2024968963 cites W2001857107 @default.
- W2024968963 cites W2002278814 @default.
- W2024968963 cites W2004689349 @default.
- W2024968963 cites W2007808077 @default.
- W2024968963 cites W2008922304 @default.
- W2024968963 cites W2009851083 @default.
- W2024968963 cites W2013246689 @default.
- W2024968963 cites W2016236490 @default.
- W2024968963 cites W2018975920 @default.
- W2024968963 cites W2022584463 @default.
- W2024968963 cites W2022893667 @default.
- W2024968963 cites W2023116564 @default.
- W2024968963 cites W2023395045 @default.
- W2024968963 cites W2028263033 @default.
- W2024968963 cites W2031762818 @default.
- W2024968963 cites W2033583033 @default.
- W2024968963 cites W2037122000 @default.
- W2024968963 cites W2043466269 @default.
- W2024968963 cites W2043765395 @default.
- W2024968963 cites W2043853830 @default.
- W2024968963 cites W2046707099 @default.
- W2024968963 cites W2049157134 @default.
- W2024968963 cites W2049194128 @default.
- W2024968963 cites W2051023523 @default.
- W2024968963 cites W2051780160 @default.
- W2024968963 cites W2054348877 @default.
- W2024968963 cites W2055166643 @default.
- W2024968963 cites W2058016005 @default.
- W2024968963 cites W2058773589 @default.
- W2024968963 cites W2068925449 @default.
- W2024968963 cites W2071880700 @default.
- W2024968963 cites W2079042284 @default.
- W2024968963 cites W2080051006 @default.
- W2024968963 cites W2082319650 @default.
- W2024968963 cites W2086013207 @default.
- W2024968963 cites W2088639594 @default.
- W2024968963 cites W2094581800 @default.
- W2024968963 cites W2095925603 @default.
- W2024968963 cites W2097805530 @default.
- W2024968963 cites W2100247616 @default.
- W2024968963 cites W2101628023 @default.
- W2024968963 cites W2102154371 @default.
- W2024968963 cites W2103619902 @default.
- W2024968963 cites W2106764227 @default.
- W2024968963 cites W2110461063 @default.
- W2024968963 cites W2111341106 @default.
- W2024968963 cites W2111568092 @default.
- W2024968963 cites W2112924289 @default.
- W2024968963 cites W2115723528 @default.
- W2024968963 cites W2117812846 @default.
- W2024968963 cites W2118290853 @default.
- W2024968963 cites W2123986423 @default.
- W2024968963 cites W2141128578 @default.
- W2024968963 cites W2144825743 @default.
- W2024968963 cites W2147426561 @default.
- W2024968963 cites W2149006664 @default.
- W2024968963 cites W2151460681 @default.
- W2024968963 cites W2153017169 @default.
- W2024968963 cites W2153327409 @default.
- W2024968963 cites W2154635123 @default.
- W2024968963 cites W2155740016 @default.