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- W2024970225 abstract "PURPOSE: To evaluate the efficacy of cyclosporine 0.05% in alleviating dry-eye signs and improving visual quality after multifocal intraocular lens (IOL) implantation. SETTING: Private practice and university medical center, New York, New York, USA. METHODS: This randomized prospective contralaterally controlled double-masked trial comprised patients scheduled to have bilateral phacoemulsification with implantation of a refractive multifocal IOL (ReZoom). Patients received twice-daily cyclosporine 0.05% in 1 eye and an artificial tear in the other eye from 1 month before to 2 months after second-eye surgery. Outcomes were evaluated at baseline and 2 months after second-eye surgery. RESULTS: The study enrolled 28 eyes of 14 patients. At baseline, there were no statistically significant between-group differences in outcome measures. Two months postoperatively, the cyclosporine group had significantly lower mean uncorrected distance visual acuity than the artificial tear group (0.11 logMAR ± 0.03 [SD] [20/25 Snellen equivalent] versus 0.19 ± 0.05 logMAR [20/30]; P = .045) as well as significantly lower mean corrected distance visual acuity (0.0 ± 0.02 logMAR [20/20] versus 0.1 ± 0.02 logMAR [20/25]; P = .005) and corneal staining scores (0.210 ± 0.07 versus 0.645 ± 0.18; P = .034). Treatment with cyclosporine 0.05% also improved contrast sensitivity, conjunctival staining, and tear breakup time. Significantly more patients preferred the eye treated with cyclosporine 0.05% to the eye treated with artificial tears (57.1% versus 14.3%; P = .007). CONCLUSION: Cyclosporine 0.05% therapy reduced dry-eye signs and improved visual quality after multifocal IOL implantation. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes." @default.
- W2024970225 created "2016-06-24" @default.
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- W2024970225 date "2010-07-01" @default.
- W2024970225 modified "2023-09-27" @default.
- W2024970225 title "Cyclosporine 0.05% to improve visual outcomes after multifocal intraocular lens implantation" @default.
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- W2024970225 doi "https://doi.org/10.1016/j.jcrs.2009.12.049" @default.
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