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• W2024970913 abstract "In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection." @default.
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• W2024970913 date "2001-09-07" @default.
• W2024970913 modified "2023-10-04" @default.
• W2024970913 title "Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses" @default.
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• W2024970913 doi "https://doi.org/10.1126/science.1062882" @default.
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