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• W2024971368 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Dec 2000EFFECT OF SILDENAFIL CITRATE ON POST-RADICAL PROSTATECTOMY ERECTILE DYSFUNCTION MARK I. FENG, SAMUEL HUANG, JOHN KAPTEIN, JON KASWICK, and SHERIF ABOSEIF MARK I. FENGMARK I. FENG More articles by this author , SAMUEL HUANGSAMUEL HUANG More articles by this author , JOHN KAPTEINJOHN KAPTEIN More articles by this author , JON KASWICKJON KASWICK More articles by this author , and SHERIF ABOSEIFSHERIF ABOSEIF More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66922-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We assess the effect of sildenafil in a subgroup of patients after prostatectomy with erectile dysfunction and determine whether nerve preservation improves sildenafil response in this subgroup. Materials and Methods: Between April 1998 and January 1999, 53 patients who had undergone radical retropubic prostatectomy and were prescribed oral sildenafil were surveyed using a confidential mail questionnaire. Of the patients 21 underwent bilateral and 15 unilateral neurovascular bundle sparing procedures, while in 17 a nonnerve sparing procedure was performed. All patients received 25 to 100 mg. sildenafil in a flexible dose escalation manner. Response, satisfaction and side effects were assessed using a modified, self-administered International Index of Erectile Function questionnaire. Response was defined as erection sufficient for intercourse. Preoperative and postoperative/pretreatment erectile functions were assessed for baseline comparison in each patient, and partner overall satisfaction with sildenafil was measured. Statistical data analysis was performed using analysis of variance and Newman-Keuls multiple comparison tests. Results: Of the 21 patients who underwent a bilateral nerve sparing procedure 15 had a positive response. Of the 15 patients who had undergone a unilateral nerve sparing procedure 12 had a positive response, and only 1 of the 17 patients who had undergone a nonnerve sparing procedure responded to sildenafil. The most commonly reported adverse events of all causes were headaches (21%), flushing (8.3%), visual disturbance (6.3%) and nasal congestion (6.3%). Conclusions: Sildenafil is an equally effective treatment for erectile dysfunction after bilateral and unilateral nerve sparing procedures, and patient response to sildenafil is confirmed by the partners. However, patients who undergo nonnerve sparing procedures do not respond satisfactorily to sildenafil. References 1 : Papaverine testing of impotent patients following nerve-sparing radical prostatectomy. J Urol1988; 139: 773. Link, Google Scholar 2 : Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study. JAMA2000; 283: 354. Google Scholar 3 : Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med1998; 338: 1397. Google Scholar 4 Huang, S., Feng, M. I., Grudinski, A. et al: Effectiveness of oral sildenafil in the treatment of erectile dysfunction. Urology, submitted for publication. Google Scholar 5 : Clinical efficacy of sildenafil citrate based on etiology and response to prior treatment. J Urol1999; 162: 722. Link, Google Scholar 6 : Treatment of erectile dysfunction after radical prostatectomy with sildenafil citrate (Viagra). Urology1998; 52: 963. Google Scholar 7 : Potency following radical prostatectomy with wide unilateral excision of the neurovascular bundle. J Urol1987; 138: 823. Link, Google Scholar 8 : Radical prostatectomy, preservation of sexual function, cancer control. The controversy. Urol Clin North Am1987; 14: 663. Google Scholar 9 : Nerve-sparing radical prostatectomy: extraprostatic tumor extension and preservation of erectile function. J Urol1985; 134: 1149. Link, Google Scholar 10 : Nerve sparing radical prostatectomy: a different view. J Urol1995; 154: 145. Link, Google Scholar 11 : Role of penile vascular injury in erectile dysfunction after radical prostatectomy. Br J Urol1994; 73: 75. Google Scholar 12 : Detailed anatomy of penile neurovascular structures: surgical significance. J Urol1989; 141: 437. Link, Google Scholar 13 : Clinical safety of oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction. Int J Impot Res1998; 10: 69. Google Scholar From the Department of Urology, Kaiser Permanente Medical Center, Los Angeles, California© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byNEHRA A, GRANTMYRE J, NADEL A, THIBONNIER M and BROCK G (2018) VARDENAFIL IMPROVED PATIENT SATISFACTION WITH ERECTILE HARDNESS, ORGASMIC FUNCTION AND SEXUAL EXPERIENCE IN MEN WITH ERECTILE DYSFUNCTION FOLLOWING NERVE SPARING RADICAL PROSTATECTOMYJournal of Urology, VOL. 173, NO. 6, (2067-2071), Online publication date: 1-Jun-2005.MONTORSI F, NATHAN H, MCCULLOUGH A, BROCK G, BRODERICK G, AHUJA S, WHITAKER S, HOOVER A, NOVACK D, MURPHY A and VARANESE L (2018) TADALAFIL IN THE TREATMENT OF ERECTILE DYSFUNCTION FOLLOWING BILATERAL NERVE SPARING RADICAL RETROPUBIC PROSTATECTOMY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED TRIALJournal of Urology, VOL. 172, NO. 3, (1036-1041), Online publication date: 1-Sep-2004.BROCK G, NEHRA A, LIPSHULTZ L, KARLIN G, GLEAVE M, SEGER M and PADMA-NATHAN H (2018) Safety and Efficacy of Vardenafil for the Treatment of Men With Erectile Dysfunction After Radical Retropubic ProstatectomyJournal of Urology, VOL. 170, NO. 4 Part 1, (1278-1283), Online publication date: 1-Oct-2003. Volume 164Issue 6December 2000Page: 1935-1938 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.KeywordspenisquestionnairesprostatectomyimpotenceMetricsAuthor Information MARK I. FENG More articles by this author SAMUEL HUANG More articles by this author JOHN KAPTEIN More articles by this author JON KASWICK More articles by this author SHERIF ABOSEIF More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2024971368 title "EFFECT OF SILDENAFIL CITRATE ON POST-RADICAL PROSTATECTOMY ERECTILE DYSFUNCTION" @default.
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