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• W2024971573 abstract "B cell genesis declines with age, but at what stage and why remains unclear. Previous studies attribute the decline in B cell production in aged mice to both environmental and cell-intrinsic defects that impact mid-to-late stream B cell precursors. However, mounting evidence suggests that the aging process may also negatively affect the earliest phases of B cell development. We review past studies on the B cells and aging question, discuss recent data suggesting that age-associated defects in B cell development reflect deficiencies in hematopoietic stem cell-proximal progenitor pools, and provide an integrative model that will hopefully facilitate further studies into this complex problem." @default.
• W2024971573 created "2016-06-24" @default.
• W2024971573 creator A5026819061 @default.
• W2024971573 creator A5066485275 @default.
• W2024971573 date "2005-10-01" @default.
• W2024971573 modified "2023-10-13" @default.
• W2024971573 title "Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells" @default.
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• W2024971573 doi "https://doi.org/10.1016/j.smim.2005.05.003" @default.
• W2024971573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15979895" @default.
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