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- W2024974928 abstract "Rotaviruses are recognized as the single most important cause of severe infantile gastroenteritis worldwide. On a world scale rotaviruses are estimated to be responsible for over 600000 deaths annually. For these reasons rotaviruses have received a high priority as a target for vaccine development. Incorporation of an effective rotavirus vaccine into the infant immunization schedule in developed countries could reduce hospitalizations due to dehydrating diarrhea in young children by 40 to 60%. More important the worldwide use of such vaccine could decrease the total number of deaths caused by diarrhea by approximately 10 to 20%. Transmission of rotaviruses occurs by the fecal-oral route providing a highly efficient mechanism for universal exposure that has circumvented regional and national cultural practice differences. The symptoms associated with rotavirus disease typically are diarrhea and vomiting accompanied by fever nausea anorexia cramping and malaise that can be mild and of shortduration or produce severe dehydration. Severe disease occurs primarily in young children most commonly among those aged 6 to 24 months. Approximately 90% of children in both developed and developing countries experience a rotavirus infection by the time they reach 3 years of age. (excerpt)" @default.
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- W2024974928 date "2007-06-01" @default.
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- W2024974928 title "RIX4414 (Rotarix™): a live attenuated human rotavirus vaccine" @default.
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- W2024974928 doi "https://doi.org/10.2223/jped.1632" @default.
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