FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024976777> ?p ?o ?g. }

• W2024976777 endingPage "1146" @default.
• W2024976777 startingPage "1139" @default.
• W2024976777 abstract "Membrane-bound glucocorticoid receptors (mGCR) are up regulated on monocytes after in vitro stimulation and in patients with rheumatoid arthritis. Caveolin-1 is critical for the transport of plasma membrane oestrogen receptors to the cell surface.To investigate the expression of mGCR in patients with systemic lupus erythematosus (SLE)-a disease with different aetiopathogenesis and treatment regimens-and to examine whether caveolin-1 is critical for the transport of mGCR to the cell surface.Frequencies of mGCR+ peripheral blood mononuclear cells were measured using high-sensitivity immunofluorescent staining and tested for correlation with SLE disease activity and glucocorticoid treatment. Semiquantitative polymerase chain reaction, immunofluorescence, recombinant expression and confocal laser-scanning microscopy were used to search for an association of mGCR with caveolin-1.The frequencies of mGCR+ monocytes (CD14+) were considerably higher in patients with SLE (n = 33) than in healthy controls (n = 58), whereas B cells (CD19+) were not different in this regard. T cells (CD3+) were always mGCR-. The frequency of mGCR+ monocytes in patients with SLE did not correlate with disease activity, but did inversely correlate with glucocorticoid dosages; this inverse correlation was confirmed by corresponding in vitro experiments with stimulated monocytes. The induced up regulation of mGCR was not accompanied by an up regulation of caveolin-1, and mGCR are not colocalised with caveolin-1 in plasma membrane caveolae.mGCR are (a) up regulated in patients with SLE and by inflammatory stimuli and (b) down regulated by glucocorticoids, suggesting a negative feedback loop to control glucocorticoid action. Drugs binding selectively to mGCR may in future prove to be of therapeutic value." @default.
• W2024976777 created "2016-06-24" @default.
• W2024976777 creator A5006647926 @default.
• W2024976777 creator A5018830075 @default.
• W2024976777 creator A5037823371 @default.
• W2024976777 creator A5044904304 @default.
• W2024976777 creator A5052150456 @default.
• W2024976777 creator A5053579209 @default.
• W2024976777 creator A5055757758 @default.
• W2024976777 creator A5058094909 @default.
• W2024976777 creator A5063858320 @default.
• W2024976777 creator A5088548224 @default.
• W2024976777 creator A5090130883 @default.
• W2024976777 creator A5091422146 @default.
• W2024976777 date "2006-09-01" @default.
• W2024976777 modified "2023-10-18" @default.
• W2024976777 title "Membrane glucocorticoid receptors are down regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1-independent expression pathway" @default.
• W2024976777 cites W1515381124 @default.
• W2024976777 cites W1521646176 @default.
• W2024976777 cites W1594606539 @default.
• W2024976777 cites W1971905187 @default.
• W2024976777 cites W1981444875 @default.
• W2024976777 cites W1981851893 @default.
• W2024976777 cites W1982365009 @default.
• W2024976777 cites W1990188546 @default.
• W2024976777 cites W1994359425 @default.
• W2024976777 cites W1994617925 @default.
• W2024976777 cites W1998395579 @default.
• W2024976777 cites W2023991614 @default.
• W2024976777 cites W2026577542 @default.
• W2024976777 cites W2029032935 @default.
• W2024976777 cites W2035240911 @default.
• W2024976777 cites W2049124236 @default.
• W2024976777 cites W2057418352 @default.
• W2024976777 cites W2057949781 @default.
• W2024976777 cites W2060364237 @default.
• W2024976777 cites W2061843136 @default.
• W2024976777 cites W2061928804 @default.
• W2024976777 cites W2063467177 @default.
• W2024976777 cites W2064999867 @default.
• W2024976777 cites W2067547922 @default.
• W2024976777 cites W2072002199 @default.
• W2024976777 cites W2076179697 @default.
• W2024976777 cites W20984170 @default.
• W2024976777 cites W2101744962 @default.
• W2024976777 cites W2104370607 @default.
• W2024976777 cites W2104492395 @default.
• W2024976777 cites W2126299335 @default.
• W2024976777 cites W2136451293 @default.
• W2024976777 cites W2137953708 @default.
• W2024976777 cites W2140158991 @default.
• W2024976777 cites W2146203649 @default.
• W2024976777 cites W2150088486 @default.
• W2024976777 cites W2159479834 @default.
• W2024976777 cites W2165085430 @default.
• W2024976777 cites W2294836073 @default.
• W2024976777 cites W2398565915 @default.
• W2024976777 cites W2409199859 @default.
• W2024976777 cites W2411857070 @default.
• W2024976777 cites W2416069164 @default.
• W2024976777 cites W2417782248 @default.
• W2024976777 cites W78569768 @default.
• W2024976777 doi "https://doi.org/10.1136/ard.2005.048272" @default.
• W2024976777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1798283" @default.
• W2024976777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16449313" @default.
• W2024976777 hasPublicationYear "2006" @default.
• W2024976777 type Work @default.
• W2024976777 sameAs 2024976777 @default.
• W2024976777 citedByCount "44" @default.
• W2024976777 countsByYear W20249767772012 @default.
• W2024976777 countsByYear W20249767772013 @default.
• W2024976777 countsByYear W20249767772014 @default.
• W2024976777 countsByYear W20249767772015 @default.
• W2024976777 countsByYear W20249767772016 @default.
• W2024976777 countsByYear W20249767772017 @default.
• W2024976777 countsByYear W20249767772019 @default.
• W2024976777 countsByYear W20249767772020 @default.
• W2024976777 countsByYear W20249767772021 @default.
• W2024976777 countsByYear W20249767772022 @default.
• W2024976777 countsByYear W20249767772023 @default.
• W2024976777 crossrefType "journal-article" @default.
• W2024976777 hasAuthorship W2024976777A5006647926 @default.
• W2024976777 hasAuthorship W2024976777A5018830075 @default.
• W2024976777 hasAuthorship W2024976777A5037823371 @default.
• W2024976777 hasAuthorship W2024976777A5044904304 @default.
• W2024976777 hasAuthorship W2024976777A5052150456 @default.
• W2024976777 hasAuthorship W2024976777A5053579209 @default.
• W2024976777 hasAuthorship W2024976777A5055757758 @default.
• W2024976777 hasAuthorship W2024976777A5058094909 @default.
• W2024976777 hasAuthorship W2024976777A5063858320 @default.
• W2024976777 hasAuthorship W2024976777A5088548224 @default.
• W2024976777 hasAuthorship W2024976777A5090130883 @default.
• W2024976777 hasAuthorship W2024976777A5091422146 @default.
• W2024976777 hasBestOaLocation W20249767772 @default.
• W2024976777 hasConcept C126322002 @default.
• W2024976777 hasConcept C134018914 @default.
• W2024976777 hasConcept C142724271 @default.
• W2024976777 hasConcept C1491633281 @default.

• next