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• W2024978055 abstract "1 To investigate the effect of experimental diabetes on the P2y purinoceptor responses of pancreatic β-cells and vascular bed, we used adenosine-5′-O-(2-thiodiphosphate) (ADPβS), a potent and stable P2y agonist. This work was performed in the isolated perfused pancreas of the rat. 2 Diabetes was induced by streptozotocin (66 mg kg−1, i.p.). Five weeks after the induction of diabetes, on the day of pancreas isolation, the animals displayed marked hyperglycaemia (37.6 ± 2.7 mm). Age-matched rats were used as controls. 3 Insulin response to a glucose stimulation from 5 to 10 mm was completely lost and stimulation of insulin release by the sulphonylurea, tolbutamide (185 μm), was drastically impaired in the diabetic pancreas (maximum responses were 1.5 ± 0.4 and 7.0 ± 1.4 ng min−1 for diabetic and age-matched rats respectively). 4 In contrast, in the diabetic pancreas ADPβS (15 μm), infused in the presence of glucose 5 mm, elicited an immediate and significant insulin release similar to that observed in the age-matched pancreas (maximum responses were 7.6 ± 1.5 and 6.7 ± 1.3 ng min−1 respectively). This ADPβS stimulating effect occurred independently of the glucose concentration (5, 8.3 and 28 mm) in the diabetic pancreas. On pancreatic vascular resistance, ADPβS induced a similar vasodilatation in diabetic and age-matched rats. 5 In conclusion, ADPβS retains its insulin stimulatory and vasodilator effects in experimental diabetes; P2y purinoceptors could therefore be considered as a new target for the development of antidiabetic drugs." @default.
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• W2024978055 date "1992-07-01" @default.
• W2024978055 modified "2023-10-18" @default.
• W2024978055 title "P2y purinoceptor responses of β cells and vascular bed are preserved in diabetic rat pancreas" @default.
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• W2024978055 doi "https://doi.org/10.1111/j.1476-5381.1992.tb14383.x" @default.
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