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• W2024981949 startingPage "e1002605" @default.
• W2024981949 abstract "Schistosoma haematobium is the etiologic agent for urogenital schistosomiasis, a major source of morbidity and mortality for more than 112 million people worldwide. Infection with S. haematobium results in a variety of immunopathologic sequelae caused by parasite oviposition within the urinary tract, which drives inflammation, hematuria, fibrosis, bladder dysfunction, and increased susceptibility to urothelial carcinoma. While humans readily develop urogenital schistosomiasis, the lack of an experimentally-tractable model has greatly impaired our understanding of the mechanisms that underlie this important disease. We have developed an improved mouse model of S. haematobium urinary tract infection that recapitulates several aspects of human urogenital schistosomiasis. Following microinjection of purified S. haematobium eggs into the bladder wall, mice consistently develop macrophage-rich granulomata that persist for at least 3 months and pass eggs in their urine. Importantly, egg-injected mice also develop urinary tract fibrosis, bladder dysfunction, and various urothelial changes morphologically reminiscent of human urogenital schistosomiasis. As expected, S. haematobium egg-induced immune responses in the immediate microenvironment, draining lymph nodes, and systemic circulation are associated with a Type 2-dominant inflammatory response, characterized by high levels of interleukin-4, eosinophils, and IgE. Taken together, our novel mouse model may help facilitate a better understanding of the unique pathophysiological mechanisms of epithelial dysfunction, tissue fibrosis, and oncogenesis associated with urogenital schistosomiasis." @default.
• W2024981949 created "2016-06-24" @default.
• W2024981949 creator A5006849587 @default.
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• W2024981949 creator A5035485445 @default.
• W2024981949 date "2012-03-29" @default.
• W2024981949 modified "2023-10-16" @default.
• W2024981949 title "A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology" @default.
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• W2024981949 doi "https://doi.org/10.1371/journal.ppat.1002605" @default.
• W2024981949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3315496" @default.
• W2024981949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22479181" @default.
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