FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024985676> ?p ?o ?g. }

• W2024985676 endingPage "337" @default.
• W2024985676 startingPage "332" @default.
• W2024985676 abstract "OBJECTIVES The aims of this study were to determine the effect of pretreatment hepatic iron concentration (HIC) on response to combination therapy with interferon and ribavirin, and to examine the change in HIC associated with this treatment. METHODS Patients with hepatitis C who underwent liver biopsy before and after combination therapy were studied retrospectively. HIC was measured from paired pre- and posttreatment liver biopsy specimens, and histologic grade and stage were recorded. RESULTS Sixty of 112 (54%) patients achieved sustained virologic response (SVR); response varied by genotype (genotype 1 (44%), genotype 2 or 3 (85%)). There was no difference in pretreatment median HIC between responders and nonresponders (404 μg/g and 394 μg/g, respectively; p = 0.31); patients with HIC ≥ 500 μg/g were not less likely to achieve SVR (OR = 1.1; 95% CI 0.5–2.3). In a multivariate analysis, factors associated with SVR included genotype 2 or 3 (OR = 12.2; 95% CI 3.1–47.8) and viral load <2 million copies/ml (OR = 3.6; 95% CI 1.3–10.0). HIC ≥ 500 μg/g did not decrease the likelihood of SVR (OR = 0.8; 95% CI 0.3–2.1). There was no significant change in HIC after combination therapy (median increase in HIC = 29.5 μg/g), and the change in HIC did not differ between responders and nonresponders (p = 0.73). CONCLUSIONS Pretreatment HIC is not an independent predictor of response to therapy with interferon and ribavirin. Combination therapy does not significantly change HIC regardless of baseline histology or virologic response." @default.
• W2024985676 created "2016-06-24" @default.
• W2024985676 creator A5036970294 @default.
• W2024985676 creator A5045112104 @default.
• W2024985676 creator A5046835105 @default.
• W2024985676 creator A5063869482 @default.
• W2024985676 creator A5064179616 @default.
• W2024985676 creator A5091028785 @default.
• W2024985676 date "2005-02-01" @default.
• W2024985676 modified "2023-10-15" @default.
• W2024985676 title "Relationships between Hepatic Iron Content and Virologic Response in Chronic Hepatitis C Patients Treated with Interferon and Ribavirin" @default.
• W2024985676 cites W1480007741 @default.
• W2024985676 cites W1675164605 @default.
• W2024985676 cites W1827150386 @default.
• W2024985676 cites W1983308333 @default.
• W2024985676 cites W1984030417 @default.
• W2024985676 cites W1994668735 @default.
• W2024985676 cites W2026270647 @default.
• W2024985676 cites W2037287515 @default.
• W2024985676 cites W2057001394 @default.
• W2024985676 cites W2064759730 @default.
• W2024985676 cites W2074412682 @default.
• W2024985676 cites W2083381459 @default.
• W2024985676 cites W2102383058 @default.
• W2024985676 cites W2118710153 @default.
• W2024985676 cites W2127685726 @default.
• W2024985676 cites W2135715865 @default.
• W2024985676 cites W2138718559 @default.
• W2024985676 cites W2152805462 @default.
• W2024985676 cites W2159870052 @default.
• W2024985676 cites W2317554121 @default.
• W2024985676 cites W304566914 @default.
• W2024985676 cites W4205336148 @default.
• W2024985676 doi "https://doi.org/10.1111/j.1572-0241.2005.41112.x" @default.
• W2024985676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15667490" @default.
• W2024985676 hasPublicationYear "2005" @default.
• W2024985676 type Work @default.
• W2024985676 sameAs 2024985676 @default.
• W2024985676 citedByCount "40" @default.
• W2024985676 countsByYear W20249856762012 @default.
• W2024985676 countsByYear W20249856762013 @default.
• W2024985676 countsByYear W20249856762014 @default.
• W2024985676 countsByYear W20249856762015 @default.
• W2024985676 countsByYear W20249856762016 @default.
• W2024985676 countsByYear W20249856762018 @default.
• W2024985676 countsByYear W20249856762019 @default.
• W2024985676 countsByYear W20249856762023 @default.
• W2024985676 crossrefType "journal-article" @default.
• W2024985676 hasAuthorship W2024985676A5036970294 @default.
• W2024985676 hasAuthorship W2024985676A5045112104 @default.
• W2024985676 hasAuthorship W2024985676A5046835105 @default.
• W2024985676 hasAuthorship W2024985676A5063869482 @default.
• W2024985676 hasAuthorship W2024985676A5064179616 @default.
• W2024985676 hasAuthorship W2024985676A5091028785 @default.
• W2024985676 hasConcept C104317684 @default.
• W2024985676 hasConcept C126322002 @default.
• W2024985676 hasConcept C135763542 @default.
• W2024985676 hasConcept C142462285 @default.
• W2024985676 hasConcept C185592680 @default.
• W2024985676 hasConcept C203014093 @default.
• W2024985676 hasConcept C2522874641 @default.
• W2024985676 hasConcept C2775934546 @default.
• W2024985676 hasConcept C2776178377 @default.
• W2024985676 hasConcept C2776455275 @default.
• W2024985676 hasConcept C2776999253 @default.
• W2024985676 hasConcept C2777766500 @default.
• W2024985676 hasConcept C2780040827 @default.
• W2024985676 hasConcept C2909179924 @default.
• W2024985676 hasConcept C3020491458 @default.
• W2024985676 hasConcept C38180746 @default.
• W2024985676 hasConcept C55493867 @default.
• W2024985676 hasConcept C71924100 @default.
• W2024985676 hasConcept C90924648 @default.
• W2024985676 hasConceptScore W2024985676C104317684 @default.
• W2024985676 hasConceptScore W2024985676C126322002 @default.
• W2024985676 hasConceptScore W2024985676C135763542 @default.
• W2024985676 hasConceptScore W2024985676C142462285 @default.
• W2024985676 hasConceptScore W2024985676C185592680 @default.
• W2024985676 hasConceptScore W2024985676C203014093 @default.
• W2024985676 hasConceptScore W2024985676C2522874641 @default.
• W2024985676 hasConceptScore W2024985676C2775934546 @default.
• W2024985676 hasConceptScore W2024985676C2776178377 @default.
• W2024985676 hasConceptScore W2024985676C2776455275 @default.
• W2024985676 hasConceptScore W2024985676C2776999253 @default.
• W2024985676 hasConceptScore W2024985676C2777766500 @default.
• W2024985676 hasConceptScore W2024985676C2780040827 @default.
• W2024985676 hasConceptScore W2024985676C2909179924 @default.
• W2024985676 hasConceptScore W2024985676C3020491458 @default.
• W2024985676 hasConceptScore W2024985676C38180746 @default.
• W2024985676 hasConceptScore W2024985676C55493867 @default.
• W2024985676 hasConceptScore W2024985676C71924100 @default.
• W2024985676 hasConceptScore W2024985676C90924648 @default.
• W2024985676 hasIssue "2" @default.
• W2024985676 hasLocation W20249856761 @default.
• W2024985676 hasLocation W20249856762 @default.
• W2024985676 hasOpenAccess W2024985676 @default.
• W2024985676 hasPrimaryLocation W20249856761 @default.
• W2024985676 hasRelatedWork W197269132 @default.

• next