FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024987459> ?p ?o ?g. }

• W2024987459 endingPage "86" @default.
• W2024987459 startingPage "74" @default.
• W2024987459 abstract "Paraquat (PQ), a widely used herbicide is a well-known free radical producing agent. The mechanistic pathways of PQ neurotoxicity were examined by assessing oxidative/nitrosative stress markers. Focus was on the role of glutathione (GSH) cycle and to examine whether the pre-treatment with enzyme glutathione reductase (GR) could protect the vulnerable brain regions (VBRs) against harmful oxidative effect of PQ. The study was conducted on Wistar rats, randomly divided in five groups: intact-control group, (n = 8) and four experimental groups (n = 24). All tested compounds were administered intrastriatally (i.s.) in one single dose. The following parameters of oxidative status were measured in the striatum, hippocampus and cortex, at 30 min, 24 h and 7 days post treatment: superoxide anion radical (O2−), nitrate (NO3−), malondialdehyde (MDA), superoxide dismutase (SOD), total GSH (tGSH) and its oxidized, disulfide form (GSSG) and glutathione peroxidase (GPx). Results obtained from the intact and the sham operated groups were not statistically different, confirming that invasive i.s. route of administration would not influence the reliability of results. Also, similar pattern of changes were observed between ipsi- and contra- lateral side of examined VBRs, indicating rapid spatial spreading of oxidative stress. Mortality of the animals (10%), within 24 h, along with symptoms of Parkinsonism, after awakening from anesthesia for 2–3 h, were observed in the PQ group, only. Increased levels of O2−, NO3− and MDA, increased ratio of GSSG/GSH and considerably high activity of GPx were measured at 30 min after the treatment. Cytotoxic effect of PQ was documented by drastic drop of all measured parameters and extremely high peak of the ratio GSSG/GSH at 24th hrs after the PQ i.s. injection. In the GR + PQ group, markedly low activity of GPx and low content of NO3− (in striatum and cortex) were measured during whole experiment, while increase value was observed only for O2−, at 7th days. We concluded that oxidative/nitrosative stress and excitotoxicity are the most important events since the early stage of PQ induced neurotoxicity. Based on the ratio GSSG/GSH, the oxidation of GSH to GSSG is probably dominant way of GHS depletion and main reason for reduced antioxidative defense against PQ harmful oxidative effect. The GR pre-treatment resulted in the absence of Parkinson’s disease-like symptoms and mortality of the rats. Additionally, oxidative/nitrosative stress did not developed, as well as almost diminished metabolism of the VBRs at 24th hours (as has been documented in the PQ group) did not occurred in the GR + PQ, suggesting a neuroprotective role for the GR in PQ induced neurotoxicity." @default.
• W2024987459 created "2016-06-24" @default.
• W2024987459 creator A5003041901 @default.
• W2024987459 creator A5003266662 @default.
• W2024987459 creator A5013162094 @default.
• W2024987459 creator A5043332144 @default.
• W2024987459 creator A5070421994 @default.
• W2024987459 creator A5085814385 @default.
• W2024987459 creator A5086840755 @default.
• W2024987459 date "2012-08-01" @default.
• W2024987459 modified "2023-10-16" @default.
• W2024987459 title "Protective role of glutathione reductase in paraquat induced neurotoxicity" @default.
• W2024987459 cites W1223981148 @default.
• W2024987459 cites W1492276448 @default.
• W2024987459 cites W1492951734 @default.
• W2024987459 cites W1505069371 @default.
• W2024987459 cites W1507082667 @default.
• W2024987459 cites W1535345009 @default.
• W2024987459 cites W1775749144 @default.
• W2024987459 cites W1891967301 @default.
• W2024987459 cites W1964491268 @default.
• W2024987459 cites W1964547713 @default.
• W2024987459 cites W1967617319 @default.
• W2024987459 cites W1968681109 @default.
• W2024987459 cites W1973573180 @default.
• W2024987459 cites W1974178505 @default.
• W2024987459 cites W1975043220 @default.
• W2024987459 cites W1975802409 @default.
• W2024987459 cites W1978870919 @default.
• W2024987459 cites W1981798442 @default.
• W2024987459 cites W1983576678 @default.
• W2024987459 cites W1991470517 @default.
• W2024987459 cites W1993873667 @default.
• W2024987459 cites W1993890087 @default.
• W2024987459 cites W1994778301 @default.
• W2024987459 cites W1995370236 @default.
• W2024987459 cites W1996311437 @default.
• W2024987459 cites W1996447559 @default.
• W2024987459 cites W1999776062 @default.
• W2024987459 cites W2002441635 @default.
• W2024987459 cites W2005248412 @default.
• W2024987459 cites W2009125386 @default.
• W2024987459 cites W2012038403 @default.
• W2024987459 cites W2017543176 @default.
• W2024987459 cites W2020538411 @default.
• W2024987459 cites W2022034337 @default.
• W2024987459 cites W2022092146 @default.
• W2024987459 cites W2025119762 @default.
• W2024987459 cites W2030374041 @default.
• W2024987459 cites W2040265315 @default.
• W2024987459 cites W2041568851 @default.
• W2024987459 cites W2043121948 @default.
• W2024987459 cites W2043815352 @default.
• W2024987459 cites W2043990301 @default.
• W2024987459 cites W2045903936 @default.
• W2024987459 cites W2046622512 @default.
• W2024987459 cites W2048243780 @default.
• W2024987459 cites W2048563316 @default.
• W2024987459 cites W2048946571 @default.
• W2024987459 cites W2049054934 @default.
• W2024987459 cites W2049145894 @default.
• W2024987459 cites W2050578486 @default.
• W2024987459 cites W2052122668 @default.
• W2024987459 cites W2054561574 @default.
• W2024987459 cites W2056063247 @default.
• W2024987459 cites W2062088744 @default.
• W2024987459 cites W2062899421 @default.
• W2024987459 cites W2066430727 @default.
• W2024987459 cites W2067769757 @default.
• W2024987459 cites W2074275799 @default.
• W2024987459 cites W2076315300 @default.
• W2024987459 cites W2078069511 @default.
• W2024987459 cites W2079822311 @default.
• W2024987459 cites W2081792021 @default.
• W2024987459 cites W2083468617 @default.
• W2024987459 cites W2083977078 @default.
• W2024987459 cites W2085144598 @default.
• W2024987459 cites W2092872254 @default.
• W2024987459 cites W2102772925 @default.
• W2024987459 cites W2118519973 @default.
• W2024987459 cites W2120459106 @default.
• W2024987459 cites W2132878122 @default.
• W2024987459 cites W2134106576 @default.
• W2024987459 cites W2136271920 @default.
• W2024987459 cites W2169714384 @default.
• W2024987459 cites W2325190709 @default.
• W2024987459 cites W2336968875 @default.
• W2024987459 cites W2946830005 @default.
• W2024987459 doi "https://doi.org/10.1016/j.cbi.2012.05.008" @default.
• W2024987459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22721943" @default.
• W2024987459 hasPublicationYear "2012" @default.
• W2024987459 type Work @default.
• W2024987459 sameAs 2024987459 @default.
• W2024987459 citedByCount "44" @default.
• W2024987459 countsByYear W20249874592013 @default.
• W2024987459 countsByYear W20249874592014 @default.
• W2024987459 countsByYear W20249874592015 @default.
• W2024987459 countsByYear W20249874592016 @default.

• next