Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024990210> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2024990210 endingPage "30" @default.
- W2024990210 startingPage "25" @default.
- W2024990210 abstract "Mechanisms by which many N-terminal propeptides facilitate folding of proteins are unknown. The maturation of such proteins from their precursors involve three stepps, namely: (1) folding of the precursor, (2) autoprocessing of the propeptide from the N terminus and (3) degradation of the cleaved propeptide. Using subtilisin E we have analyzed the mechanism of propeptide-mediated protein folding. Two active site mutations allow us to trap intermediates at stages of autoprocessing and degradation. An analysis of these intermediates has shown the existence of a molten-globule-like intermediate on the folding pathway. After autoprocessing of the propeptide, this intermediate undergoes a structural reorganization which reduces solvent-accessible hydrophobic surface area and increases the amount of its tertiary structure. Removal of the propeptide from the mature enzyme in this intermediate state occurs only by proteolytic degradation and contributes to the stability of the active enzyme." @default.
- W2024990210 created "2016-06-24" @default.
- W2024990210 creator A5030465724 @default.
- W2024990210 creator A5066661471 @default.
- W2024990210 date "1995-09-01" @default.
- W2024990210 modified "2023-09-25" @default.
- W2024990210 title "Folding Pathway Mediated by an Intramolecular Chaperone: Characterization of the Structural Changes in Pro-subtilisin E Coincident with Autoprocess ing" @default.
- W2024990210 doi "https://doi.org/10.1006/jmbi.1995.0472" @default.
- W2024990210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7666430" @default.
- W2024990210 hasPublicationYear "1995" @default.
- W2024990210 type Work @default.
- W2024990210 sameAs 2024990210 @default.
- W2024990210 citedByCount "49" @default.
- W2024990210 countsByYear W20249902102012 @default.
- W2024990210 countsByYear W20249902102013 @default.
- W2024990210 countsByYear W20249902102015 @default.
- W2024990210 countsByYear W20249902102016 @default.
- W2024990210 countsByYear W20249902102017 @default.
- W2024990210 countsByYear W20249902102020 @default.
- W2024990210 crossrefType "journal-article" @default.
- W2024990210 hasAuthorship W2024990210A5030465724 @default.
- W2024990210 hasAuthorship W2024990210A5066661471 @default.
- W2024990210 hasConcept C119599485 @default.
- W2024990210 hasConcept C12554922 @default.
- W2024990210 hasConcept C127413603 @default.
- W2024990210 hasConcept C142724271 @default.
- W2024990210 hasConcept C181199279 @default.
- W2024990210 hasConcept C185592680 @default.
- W2024990210 hasConcept C204328495 @default.
- W2024990210 hasConcept C2775962898 @default.
- W2024990210 hasConcept C2776545253 @default.
- W2024990210 hasConcept C2779811187 @default.
- W2024990210 hasConcept C41183919 @default.
- W2024990210 hasConcept C47701112 @default.
- W2024990210 hasConcept C55493867 @default.
- W2024990210 hasConcept C71240020 @default.
- W2024990210 hasConcept C71924100 @default.
- W2024990210 hasConcept C7860815 @default.
- W2024990210 hasConcept C86803240 @default.
- W2024990210 hasConceptScore W2024990210C119599485 @default.
- W2024990210 hasConceptScore W2024990210C12554922 @default.
- W2024990210 hasConceptScore W2024990210C127413603 @default.
- W2024990210 hasConceptScore W2024990210C142724271 @default.
- W2024990210 hasConceptScore W2024990210C181199279 @default.
- W2024990210 hasConceptScore W2024990210C185592680 @default.
- W2024990210 hasConceptScore W2024990210C204328495 @default.
- W2024990210 hasConceptScore W2024990210C2775962898 @default.
- W2024990210 hasConceptScore W2024990210C2776545253 @default.
- W2024990210 hasConceptScore W2024990210C2779811187 @default.
- W2024990210 hasConceptScore W2024990210C41183919 @default.
- W2024990210 hasConceptScore W2024990210C47701112 @default.
- W2024990210 hasConceptScore W2024990210C55493867 @default.
- W2024990210 hasConceptScore W2024990210C71240020 @default.
- W2024990210 hasConceptScore W2024990210C71924100 @default.
- W2024990210 hasConceptScore W2024990210C7860815 @default.
- W2024990210 hasConceptScore W2024990210C86803240 @default.
- W2024990210 hasIssue "1" @default.
- W2024990210 hasLocation W20249902101 @default.
- W2024990210 hasLocation W20249902102 @default.
- W2024990210 hasOpenAccess W2024990210 @default.
- W2024990210 hasPrimaryLocation W20249902101 @default.
- W2024990210 hasRelatedWork W1978656443 @default.
- W2024990210 hasRelatedWork W1985436124 @default.
- W2024990210 hasRelatedWork W1987878848 @default.
- W2024990210 hasRelatedWork W2024990210 @default.
- W2024990210 hasRelatedWork W2026727532 @default.
- W2024990210 hasRelatedWork W2038534302 @default.
- W2024990210 hasRelatedWork W2055523320 @default.
- W2024990210 hasRelatedWork W2115346068 @default.
- W2024990210 hasRelatedWork W2116740021 @default.
- W2024990210 hasRelatedWork W2167546940 @default.
- W2024990210 hasVolume "252" @default.
- W2024990210 isParatext "false" @default.
- W2024990210 isRetracted "false" @default.
- W2024990210 magId "2024990210" @default.
- W2024990210 workType "article" @default.