FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024991780> ?p ?o ?g. }

• W2024991780 endingPage "e3367" @default.
• W2024991780 startingPage "e3367" @default.
• W2024991780 abstract "Cystic fibrosis is characterized by recurring pulmonary exacerbations that lead to the deterioration of lung function and eventual lung failure. Excessive inflammatory responses by airway epithelia have been linked to the overproduction of the inflammatory cytokine IL-6 and IL-8. The mechanism by which this occurs is not fully understood, but normal IL-1β mediated activation of the production of these cytokines occurs via H2O2 dependent signaling. Therefore, we speculated that CFTR dysfunction causes alterations in the regulation of steady state H2O2. We found significantly elevated levels of H2O2 in three cultured epithelial cell models of CF, one primary and two immortalized. Increases in H2O2 heavily contributed to the excessive IL-6 and IL-8 production in CF epithelia. Proteomic analysis of three in vitro and two in vivo models revealed a decrease in antioxidant proteins that regulate H2O2 processing, by ≥2 fold in CF vs. matched normal controls. When cells are stimulated, differential expression in CF versus normal is enhanced; corresponding to an increase in H2O2 mediated production of IL-6 and IL-8. The cause of this redox imbalance is a decrease by ∼70% in CF cells versus normal in the expression and activity of the transcription factor Nrf-2. Inhibition of CFTR function in normal cells produced this phenotype, while N-acetyl cysteine, selenium, an activator of Nrf-2, and the overexpression of Nrf-2 all normalized H2O2 processing and decreased IL-6 and IL-8 to normal levels, in CF cells. We conclude that a paradoxical decrease in Nrf-2 driven antioxidant responses in CF epithelia results in an increase in steady state H2O2, which in turn contributes to the overproduction of the pro-inflammatory cytokines IL-6 and IL-8. Treatment with antioxidants can ameliorate exaggerated cytokine production without affecting normal responses." @default.
• W2024991780 created "2016-06-24" @default.
• W2024991780 creator A5009684381 @default.
• W2024991780 creator A5041592437 @default.
• W2024991780 creator A5061676438 @default.
• W2024991780 creator A5065080692 @default.
• W2024991780 creator A5075065209 @default.
• W2024991780 creator A5085985069 @default.
• W2024991780 date "2008-10-10" @default.
• W2024991780 modified "2023-10-16" @default.
• W2024991780 title "Dysfunction of Nrf-2 in CF Epithelia Leads to Excess Intracellular H2O2 and Inflammatory Cytokine Production" @default.
• W2024991780 cites W1501442799 @default.
• W2024991780 cites W1822904756 @default.
• W2024991780 cites W1955547739 @default.
• W2024991780 cites W1966528088 @default.
• W2024991780 cites W1967291007 @default.
• W2024991780 cites W1971290197 @default.
• W2024991780 cites W1985931909 @default.
• W2024991780 cites W1998338448 @default.
• W2024991780 cites W2003055213 @default.
• W2024991780 cites W2004517091 @default.
• W2024991780 cites W2011683519 @default.
• W2024991780 cites W2021980585 @default.
• W2024991780 cites W2024007859 @default.
• W2024991780 cites W2030819680 @default.
• W2024991780 cites W2031869195 @default.
• W2024991780 cites W2041817922 @default.
• W2024991780 cites W2058520274 @default.
• W2024991780 cites W2058530636 @default.
• W2024991780 cites W2061402035 @default.
• W2024991780 cites W2068721110 @default.
• W2024991780 cites W2075028026 @default.
• W2024991780 cites W2079464266 @default.
• W2024991780 cites W2081941108 @default.
• W2024991780 cites W2083331590 @default.
• W2024991780 cites W2085201901 @default.
• W2024991780 cites W2085861288 @default.
• W2024991780 cites W2089326429 @default.
• W2024991780 cites W2092668553 @default.
• W2024991780 cites W2094696148 @default.
• W2024991780 cites W2098768419 @default.
• W2024991780 cites W2106336240 @default.
• W2024991780 cites W2106837648 @default.
• W2024991780 cites W2111979473 @default.
• W2024991780 cites W2112299827 @default.
• W2024991780 cites W2120222530 @default.
• W2024991780 cites W2123273404 @default.
• W2024991780 cites W2127361574 @default.
• W2024991780 cites W2137905555 @default.
• W2024991780 cites W2143301186 @default.
• W2024991780 cites W2146903865 @default.
• W2024991780 cites W2147924866 @default.
• W2024991780 cites W2153390391 @default.
• W2024991780 cites W2181803248 @default.
• W2024991780 cites W2185747003 @default.
• W2024991780 cites W2480069414 @default.
• W2024991780 cites W2999065750 @default.
• W2024991780 doi "https://doi.org/10.1371/journal.pone.0003367" @default.
• W2024991780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2563038" @default.
• W2024991780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18846238" @default.
• W2024991780 hasPublicationYear "2008" @default.
• W2024991780 type Work @default.
• W2024991780 sameAs 2024991780 @default.
• W2024991780 citedByCount "90" @default.
• W2024991780 countsByYear W20249917802012 @default.
• W2024991780 countsByYear W20249917802013 @default.
• W2024991780 countsByYear W20249917802014 @default.
• W2024991780 countsByYear W20249917802015 @default.
• W2024991780 countsByYear W20249917802016 @default.
• W2024991780 countsByYear W20249917802017 @default.
• W2024991780 countsByYear W20249917802018 @default.
• W2024991780 countsByYear W20249917802019 @default.
• W2024991780 countsByYear W20249917802020 @default.
• W2024991780 countsByYear W20249917802021 @default.
• W2024991780 countsByYear W20249917802022 @default.
• W2024991780 countsByYear W20249917802023 @default.
• W2024991780 crossrefType "journal-article" @default.
• W2024991780 hasAuthorship W2024991780A5009684381 @default.
• W2024991780 hasAuthorship W2024991780A5041592437 @default.
• W2024991780 hasAuthorship W2024991780A5061676438 @default.
• W2024991780 hasAuthorship W2024991780A5065080692 @default.
• W2024991780 hasAuthorship W2024991780A5075065209 @default.
• W2024991780 hasAuthorship W2024991780A5085985069 @default.
• W2024991780 hasBestOaLocation W20249917801 @default.
• W2024991780 hasConcept C126322002 @default.
• W2024991780 hasConcept C185592680 @default.
• W2024991780 hasConcept C203014093 @default.
• W2024991780 hasConcept C2776914184 @default.
• W2024991780 hasConcept C2776938444 @default.
• W2024991780 hasConcept C2778690821 @default.
• W2024991780 hasConcept C71924100 @default.
• W2024991780 hasConcept C79879829 @default.
• W2024991780 hasConcept C86803240 @default.
• W2024991780 hasConcept C95444343 @default.
• W2024991780 hasConceptScore W2024991780C126322002 @default.
• W2024991780 hasConceptScore W2024991780C185592680 @default.
• W2024991780 hasConceptScore W2024991780C203014093 @default.
• W2024991780 hasConceptScore W2024991780C2776914184 @default.

• next