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• W2024991888 abstract "Interleukin 3 (IL-3) is a cytokine produced by activated T lymphocytes that is best understood as a hematopoietic growth and differentiation factor. Production of IL-3 by other cell types is controversial; while certain transformed non-lymphocyte cell lines can produce IL-3, it is generally assumed that their non-transformed counterparts do not. It has been previously reported that Pam 212, a transformed murine keratinocyte cell line, produces IL-3. In this study we report that IL-3 can also be secreted by normal murine keratinocytes. Using a cell line (FL5.12) which is responsive to IL-3 and not to other keratinocyte derived cytokines, (e.g. GM-CSF, IL-1 and IL-6), we tested conditioned media from cultures of normal neonatal keratinocytes for biologically active IL-3. These media stimulated the proliferation of FL5.12, and the effect could be neutralized by specific antibodies to IL-3. The presence of IL-3 mRNA was demonstrated by polymerase chain reaction (PCR) amplification of reverse transcribed IL-3 mRNA from cultured normal neonatal keratinocytes and confirmed by Southern blot analysis. By similar techniques, IL-3 mRNA could be identified in freshly isolated neonatal epidermis but not dermis. These data indicated that IL-3 is produced by keratinocytes in the skin of normal neonatal mice, raising the likelihood that the neonatal epidermal microenvironment may have hematopoietic or lymphopoietic properties." @default.
• W2024991888 created "2016-06-24" @default.
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• W2024991888 date "1993-05-01" @default.
• W2024991888 modified "2023-09-23" @default.
• W2024991888 title "Production of IL-3 by non-transformed primary neonatal murine keratinocytes: Evidence for constitutive IL-3 gene expression in neonatal epidermis" @default.
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• W2024991888 doi "https://doi.org/10.1016/1043-4666(93)90011-s" @default.
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