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• W2024993629 abstract "Carbonic anhydrase II, belonging to one of the most important enzyme groups of the human body, is a well-studied isozyme from the family of the carbonic anhydrases. Since it is involved in several physiological processes, it has been a pharmaceutical target for many years. In this study we synthesized a number of sulfamates derived from pentacyclic methyl triterpenoates, and we demonstrate their potential as carbonic anhydrase II inhibitors using the well-established photometric 4-nitrophenyl acetate assay. Inhibition constants, as an indicator of their inhibition strength, were in the micromolar range; one compound (10, methyl (3β) 3-(aminosulfonyloxy)-oleanoate) showed a Ki value as low as 0.3 μM. This Ki value is comparable to that of acetazolamide which is a potent carbonic anhydrase inhibitor and a drug for the treatment of glaucoma." @default.
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• W2024993629 date "2014-10-01" @default.
• W2024993629 modified "2023-09-23" @default.
• W2024993629 title "Sulfamates of methyl triterpenoates are effective and competitive inhibitors of carbonic anhydrase II" @default.
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• W2024993629 doi "https://doi.org/10.1016/j.ejmech.2014.08.051" @default.
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