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- W2024993668 abstract "SHP1 and SHP2 tyrosine phosphatases have both been implicated in signalling pathways downstream of the interleukin-3 (IL-3) receptor. We have investigated the co-association of SHP1 and SHP2 with tyrosine-phosphorylated proteins in IL-3-dependent BaF/3 cells. We demonstrate that both SHP1 and SHP2 associate with Aic2A (β chain of the IL-3 receptor), Gab2 and the paired inhibitory receptor B (PIR-B). The individual SH2 domains of SHP2 can independently bind Gab2, potentially important for the adapter function of SHP2. Association of both phosphatases with Aic2A and Gab2 increases upon IL-3 treatment. Recruitment of SHP1 to PIR-B also increases in response to IL-3, suggesting a functional link between inhibitory and cytokine receptor signalling. Aic2A is a rapid target for dephosphorylation following IL-3 stimulation and substrate-trapping versions of both phosphatases identify Aic2A and Gab2 as substrates for SHP1 and SHP2. These studies suggest that SH2–domain interactions are important for targetting these phosphatases to their substrates." @default.
- W2024993668 created "2016-06-24" @default.
- W2024993668 creator A5019963272 @default.
- W2024993668 creator A5044017320 @default.
- W2024993668 creator A5072637924 @default.
- W2024993668 date "2002-03-01" @default.
- W2024993668 modified "2023-10-13" @default.
- W2024993668 title "Molecular interactions of SHP1 and SHP2 in IL-3-signalling" @default.
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- W2024993668 doi "https://doi.org/10.1016/s0898-6568(01)00241-8" @default.
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