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- W2024993910 abstract "The intestinal intraepithelial lymphocytes (IEL) represent multi-lineage T cell populations. In addition to a major γδTCR+ T cell subset, many IEL express αβTCRs and they can be separated into αβ sublineages. Some TCRαβ+IEL have characteristics in common with conventional TCRαβ+T cells whereas others share an unconventional phenotype with their TCRγδ+ counterparts. Because the latter are enriched for autoreactive TCRs and can be generated in the absence of a thymus, it has long been postulated that some IEL subsets develop locally in the intestine. Several new data however, indicate that under physiological conditions, IEL require a thymic education that directs lineage commitment and functional differentiation. This review will discuss the contributions of the thymus in shaping the various intestinal IEL sublineages." @default.
- W2024993910 created "2016-06-24" @default.
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- W2024993910 date "2008-04-01" @default.
- W2024993910 modified "2023-09-27" @default.
- W2024993910 title "The thymus chapter in the life of gut-specific intra epithelial lymphocytes" @default.
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- W2024993910 doi "https://doi.org/10.1016/j.coi.2008.03.009" @default.
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