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- W2024994244 abstract "A method is described to estimate the turnover time of the mucus gel layer in chronically isolated intestinal loops in the rat during perfusion with isotonic saline. Measuring the concentration of a marker substance (total hexose) in the perfusion solution allowed calculation of the volume of produced mucus (Vp) to be in the range between 0.03 and 0.16 μl min−1 cm−1. The volume of the adhering mucus gel layer (Va) was calculated using anatomical data from the literature to be 7.78 ± 0.32 μlcm−1. Hence, the turnover time of the mucus gel layer as given by the quotient of Va/Vp could be estimated to vary in the range between 47 and 270 min. This time scale is well comparable with the mean residence time found for mucoadhesive microspheres in earlier experiments using the same animal model. It is concluded that mucus turnover probably represents a crucial physiological factor for the concept of mucoadhesive dosage forms." @default.
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- W2024994244 date "1991-04-01" @default.
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- W2024994244 title "An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop" @default.
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- W2024994244 doi "https://doi.org/10.1016/0378-5173(91)90287-x" @default.
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