Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024994987> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2024994987 endingPage "e71" @default.
- W2024994987 startingPage "e71" @default.
- W2024994987 abstract "Background: HIV infection and the use of antiretroviral therapy can lead to clinical and metabolic changes first described in adults and later in children and adolescents. In this study, we evaluated the presence of lipodystrophy, dyslipidemia, hyperglycemia and insulin resistance determined by biochemical parameters and clinical assessment. Methods: Prospective transversal study including 40 prepubertal children and adolescents of both gender, aged 7 to 12 years, attended at the Pediatric Infectious Disease Clinic - Universidade Federal de São Paulo, São Paulo city, Brazil, from august to december, 2008. Epidemiological parameters (age,sex, HIV transmission), clinical and immune status (CDC, 1994) and HAART were recorded. Presence of clinical signs of lipodystrophy was assessed by a trained clinician. Lipid panel, glucose and insulin levels were evaluated after an overnight fast (Kwiterovich, 2008; ADA, 2008). HOMA-IR was calculated to assess insulin resistance. Statistical tests such as t-distribution and chi-squared test were performed. Statistical significance was considered as P < 0.05, data were analysed using STATA 8.0 software. Results: The mean age was 9,8 ± 1,2 years, 50% were boys, 82,5% children from B e C categories and 97,5% were infected by vertical transmission. Lipodystrophy was present in 11 patients (27,5%), while hypertriglyceridaemia, hypercholesterolaemia, low HDL cholesterol levels and high LDL cholesterol levels were present in 40%, 32,5%, 32,5% and 17,5% respectively. The prevalence of hyperglycemia (5%) and insulin resistance (2,5%) was lower in these patients. There was a significant association between lipodystrophy and insulin levels (P = 0,043). In our study, 52,5% patients received protease inhibitors, which showed significant association with higher levels of triglycerides (P = 0,003) and total cholesterol (P = 0,005). Conclusion: There was a higher prevalence of lipodystrophy and dyslipidemia in comparison with hyperglycemia and insulin resistance. The protease inhibitors were associated with impaired lipid metabolism, increasing the risk of early cardiovascular disease. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive" @default.
- W2024994987 created "2016-06-24" @default.
- W2024994987 creator A5000305115 @default.
- W2024994987 creator A5006871170 @default.
- W2024994987 creator A5024043332 @default.
- W2024994987 creator A5030916868 @default.
- W2024994987 creator A5050226249 @default.
- W2024994987 creator A5065104796 @default.
- W2024994987 creator A5066492948 @default.
- W2024994987 creator A5076226103 @default.
- W2024994987 date "2010-03-01" @default.
- W2024994987 modified "2023-10-01" @default.
- W2024994987 title "Metabolic changes in HIV-infected children and adolescents from São Paulo city, Brazil" @default.
- W2024994987 doi "https://doi.org/10.1016/j.ijid.2010.02.1646" @default.
- W2024994987 hasPublicationYear "2010" @default.
- W2024994987 type Work @default.
- W2024994987 sameAs 2024994987 @default.
- W2024994987 citedByCount "0" @default.
- W2024994987 crossrefType "journal-article" @default.
- W2024994987 hasAuthorship W2024994987A5000305115 @default.
- W2024994987 hasAuthorship W2024994987A5006871170 @default.
- W2024994987 hasAuthorship W2024994987A5024043332 @default.
- W2024994987 hasAuthorship W2024994987A5030916868 @default.
- W2024994987 hasAuthorship W2024994987A5050226249 @default.
- W2024994987 hasAuthorship W2024994987A5065104796 @default.
- W2024994987 hasAuthorship W2024994987A5066492948 @default.
- W2024994987 hasAuthorship W2024994987A5076226103 @default.
- W2024994987 hasBestOaLocation W20249949871 @default.
- W2024994987 hasConcept C107130276 @default.
- W2024994987 hasConcept C126322002 @default.
- W2024994987 hasConcept C142462285 @default.
- W2024994987 hasConcept C187212893 @default.
- W2024994987 hasConcept C188816634 @default.
- W2024994987 hasConcept C203014093 @default.
- W2024994987 hasConcept C2777391703 @default.
- W2024994987 hasConcept C2778096610 @default.
- W2024994987 hasConcept C2779134260 @default.
- W2024994987 hasConcept C2779306644 @default.
- W2024994987 hasConcept C2780941825 @default.
- W2024994987 hasConcept C2993143319 @default.
- W2024994987 hasConcept C3013748606 @default.
- W2024994987 hasConcept C65409693 @default.
- W2024994987 hasConcept C71924100 @default.
- W2024994987 hasConceptScore W2024994987C107130276 @default.
- W2024994987 hasConceptScore W2024994987C126322002 @default.
- W2024994987 hasConceptScore W2024994987C142462285 @default.
- W2024994987 hasConceptScore W2024994987C187212893 @default.
- W2024994987 hasConceptScore W2024994987C188816634 @default.
- W2024994987 hasConceptScore W2024994987C203014093 @default.
- W2024994987 hasConceptScore W2024994987C2777391703 @default.
- W2024994987 hasConceptScore W2024994987C2778096610 @default.
- W2024994987 hasConceptScore W2024994987C2779134260 @default.
- W2024994987 hasConceptScore W2024994987C2779306644 @default.
- W2024994987 hasConceptScore W2024994987C2780941825 @default.
- W2024994987 hasConceptScore W2024994987C2993143319 @default.
- W2024994987 hasConceptScore W2024994987C3013748606 @default.
- W2024994987 hasConceptScore W2024994987C65409693 @default.
- W2024994987 hasConceptScore W2024994987C71924100 @default.
- W2024994987 hasLocation W20249949871 @default.
- W2024994987 hasOpenAccess W2024994987 @default.
- W2024994987 hasPrimaryLocation W20249949871 @default.
- W2024994987 hasRelatedWork W2059610281 @default.
- W2024994987 hasRelatedWork W2111784701 @default.
- W2024994987 hasRelatedWork W2133417811 @default.
- W2024994987 hasRelatedWork W2143515601 @default.
- W2024994987 hasRelatedWork W2371246552 @default.
- W2024994987 hasRelatedWork W2559842761 @default.
- W2024994987 hasRelatedWork W2793900409 @default.
- W2024994987 hasRelatedWork W2916721244 @default.
- W2024994987 hasRelatedWork W3081510581 @default.
- W2024994987 hasRelatedWork W3029090614 @default.
- W2024994987 hasVolume "14" @default.
- W2024994987 isParatext "false" @default.
- W2024994987 isRetracted "false" @default.
- W2024994987 magId "2024994987" @default.
- W2024994987 workType "article" @default.