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- W2024995125 abstract "Abstract The highly dynamic nature of voltage‐gated Na + channel (VGSC) expression and its controlling mechanism(s) are not well understood. In this study, we investigated the possible involvement of nerve growth factor (NGF) in regulating VGSC activity in the strongly metastatic Mat‐LyLu cell model of rat prostate cancer (PCa). NGF increased peak VGSC current density in a time‐ and dose‐dependent manner. NGF also shifted voltage to peak and the half‐activation voltage to more positive potentials, and produced currents with faster kinetics of activation; sensitivity to the VGSC blocker tetrodotoxin (TTX) was not affected. The NGF‐induced increase in peak VGSC current density was suppressed by both the pan‐trk antagonist K252a, and the protein kinase A (PKA) inhibitor KT5720. NGF did not affect the Nav1.7 mRNA level, but the total VGSC α‐subunit protein level was upregulated. NGF potentiated the cells' migration in Transwell assays, and this was not affected by TTX. We concluded that NGF upregulated functional VGSC expression in Mat‐LyLu cells, with PKA as a signaling intermediate, but enhancement of migration by NGF was independent of VGSC activity. J. Cell. Physiol. 210: 602–608, 2007. © 2006 Wiley‐Liss, Inc." @default.
- W2024995125 created "2016-06-24" @default.
- W2024995125 creator A5011222818 @default.
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- W2024995125 date "2006-12-05" @default.
- W2024995125 modified "2023-10-10" @default.
- W2024995125 title "Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell line" @default.
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- W2024995125 doi "https://doi.org/10.1002/jcp.20846" @default.
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