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- W2024996050 abstract "We prepared 5-HT(1A) receptor ligands (S)-N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]-3-[11C]methylthiobenzamide ([11C](S)-PPMMB) (Ki = 4.3 nM) and the less active [(11)C](R)-PPMMB (Ki = 160 nM) by reduction of the disulfide dimer and subsequent [(11)C]methylation of demethyl (S)- and (R)-PPMMB, respectively. Both radioligands showed similar brain distribution in mice with relatively higher affinity for the hippocampus being rich in 5-HT(1A) receptors than for other brain regions. Uptake of [(11)C](S)-PPMMB was not reduced by carrier-loading nor by pretreatment with 5-HT(1A) receptor ligands. [(11)C](S)-PPMMB is therefore not a suitable radioligand for mapping 5-HT(1A) receptors using positron emission tomography." @default.
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- W2024996050 date "2002-08-01" @default.
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- W2024996050 title "Synthesis and evaluation of 11C-labeled (S)-N-{[1-(2-phenylethyl) pyrrolidin-2-yl]methyl}-3-methylthiobenzamide as a PET 5-HT1A receptor ligand" @default.
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- W2024996050 doi "https://doi.org/10.1016/s0969-8051(02)00305-0" @default.
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