FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024996093> ?p ?o ?g. }

• W2024996093 endingPage "e69760" @default.
• W2024996093 startingPage "e69760" @default.
• W2024996093 abstract "Colorectal cancer is the third leading cause of cancer-related death in the western world. In vitro and in vivo experiments showed that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can attenuate the proliferation of cancer cells, including colon cancer, and increase the efficacy of various anticancer drugs. However, these studies address the effects of n-3 PUFAs on the bulk of the tumor cells and not on the undifferentiated colon cancer stem-like cells (CSLCs) that are responsible for tumor formation and maintenance. CSLCs have also been linked to the acquisition of chemotherapy resistance and to tumor relapse. Colon CSLCs have been immunophenotyped using several antibodies against cellular markers including CD133, CD44, EpCAM, and ALDH. Anti-CD133 has been used to isolate a population of colon cancer cells that retains stem cells properties (CSLCs) from both established cell lines and primary cell cultures. We demonstrated that the n-3 PUFA, eicosapentaenoic acid (EPA), was actively incorporated into the membrane lipids of COLO 320 DM cells. 25 uM EPA decreased the cell number of the overall population of cancer cells, but not of the CD133 (+) CSLCs. Also, we observed that EPA induced down-regulation of CD133 expression and up-regulation of colonic epithelium differentiation markers, Cytokeratin 20 (CK20) and Mucin 2 (MUC2). Finally, we demonstrated that EPA increased the sensitivity of COLO 320 DM cells (total population) to both standard-of-care chemotherapies (5-Fluorouracil and oxaliplatin), whereas EPA increased the sensitivity of the CD133 (+) CSLCs to only 5-Fluorouracil." @default.
• W2024996093 created "2016-06-24" @default.
• W2024996093 creator A5037315214 @default.
• W2024996093 creator A5038049613 @default.
• W2024996093 creator A5038787397 @default.
• W2024996093 creator A5068242249 @default.
• W2024996093 date "2013-07-16" @default.
• W2024996093 modified "2023-10-15" @default.
• W2024996093 title "Omega-3 Eicosapentaenoic Acid Decreases CD133 Colon Cancer Stem-Like Cell Marker Expression While Increasing Sensitivity to Chemotherapy" @default.
• W2024996093 cites W1487240281 @default.
• W2024996093 cites W1968501452 @default.
• W2024996093 cites W1969290499 @default.
• W2024996093 cites W1969819377 @default.
• W2024996093 cites W1970347121 @default.
• W2024996093 cites W1974693247 @default.
• W2024996093 cites W1976470241 @default.
• W2024996093 cites W1977864526 @default.
• W2024996093 cites W1979647727 @default.
• W2024996093 cites W1988300812 @default.
• W2024996093 cites W1990589849 @default.
• W2024996093 cites W1998052180 @default.
• W2024996093 cites W2000776312 @default.
• W2024996093 cites W2006452399 @default.
• W2024996093 cites W2008090904 @default.
• W2024996093 cites W2020210568 @default.
• W2024996093 cites W2022236645 @default.
• W2024996093 cites W2022594395 @default.
• W2024996093 cites W2029231546 @default.
• W2024996093 cites W2041491387 @default.
• W2024996093 cites W2043103956 @default.
• W2024996093 cites W2050227287 @default.
• W2024996093 cites W2051055358 @default.
• W2024996093 cites W2054205257 @default.
• W2024996093 cites W2055914818 @default.
• W2024996093 cites W2056935575 @default.
• W2024996093 cites W2058235769 @default.
• W2024996093 cites W2059539345 @default.
• W2024996093 cites W2059972525 @default.
• W2024996093 cites W2060389571 @default.
• W2024996093 cites W2060551076 @default.
• W2024996093 cites W2062205986 @default.
• W2024996093 cites W2065384280 @default.
• W2024996093 cites W2068639464 @default.
• W2024996093 cites W2070368600 @default.
• W2024996093 cites W2072009845 @default.
• W2024996093 cites W2072083447 @default.
• W2024996093 cites W2078310910 @default.
• W2024996093 cites W2088629757 @default.
• W2024996093 cites W2089703995 @default.
• W2024996093 cites W2097702986 @default.
• W2024996093 cites W2100837269 @default.
• W2024996093 cites W2102085111 @default.
• W2024996093 cites W2107277218 @default.
• W2024996093 cites W2127516991 @default.
• W2024996093 cites W2129644533 @default.
• W2024996093 cites W2130654131 @default.
• W2024996093 cites W2133845866 @default.
• W2024996093 cites W2139544398 @default.
• W2024996093 cites W2147056998 @default.
• W2024996093 cites W2155654820 @default.
• W2024996093 cites W2156367614 @default.
• W2024996093 cites W2160138651 @default.
• W2024996093 cites W2164277862 @default.
• W2024996093 cites W2171232394 @default.
• W2024996093 cites W2400419313 @default.
• W2024996093 cites W2419605677 @default.
• W2024996093 cites W3175495027 @default.
• W2024996093 cites W4361869938 @default.
• W2024996093 doi "https://doi.org/10.1371/journal.pone.0069760" @default.
• W2024996093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3713061" @default.
• W2024996093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23874993" @default.
• W2024996093 hasPublicationYear "2013" @default.
• W2024996093 type Work @default.
• W2024996093 sameAs 2024996093 @default.
• W2024996093 citedByCount "48" @default.
• W2024996093 countsByYear W20249960932014 @default.
• W2024996093 countsByYear W20249960932015 @default.
• W2024996093 countsByYear W20249960932016 @default.
• W2024996093 countsByYear W20249960932017 @default.
• W2024996093 countsByYear W20249960932018 @default.
• W2024996093 countsByYear W20249960932019 @default.
• W2024996093 countsByYear W20249960932020 @default.
• W2024996093 countsByYear W20249960932021 @default.
• W2024996093 countsByYear W20249960932022 @default.
• W2024996093 countsByYear W20249960932023 @default.
• W2024996093 crossrefType "journal-article" @default.
• W2024996093 hasAuthorship W2024996093A5037315214 @default.
• W2024996093 hasAuthorship W2024996093A5038049613 @default.
• W2024996093 hasAuthorship W2024996093A5038787397 @default.
• W2024996093 hasAuthorship W2024996093A5068242249 @default.
• W2024996093 hasBestOaLocation W20249960931 @default.
• W2024996093 hasConcept C121608353 @default.
• W2024996093 hasConcept C126322002 @default.
• W2024996093 hasConcept C1491633281 @default.
• W2024996093 hasConcept C19038510 @default.
• W2024996093 hasConcept C203014093 @default.
• W2024996093 hasConcept C2776091944 @default.
• W2024996093 hasConcept C2780932548 @default.

• next