Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024996448> ?p ?o ?g. }
- W2024996448 endingPage "51" @default.
- W2024996448 startingPage "44" @default.
- W2024996448 abstract "A simple and efficient method for the synthesis of highly diverse pyrano[2,3-c]pyridazines was achieved by a one pot multicomponent reaction using piperidine as the organocatalyst. The synthesis of a series of heterocyclic derivatives with varying functionality (e.g. thiazine, tetrazole and pyrimidine) incorporating the pyrano[2,3-c]pyridazine moiety were achieved via reaction of 2a–e with different reagents. The structures of the synthesized derivatives were elucidated by FTIR, MS, 1H and 13C NMR spectroscopy. A number of the newly synthesized targeted compounds 2b–e, 3a–c and 4a–c were evaluated for their in vitro antibacterial activity and were compared with chloramphenicol and nystatin as broad spectrum reference standard antibiotics. Tests were carried out against Staphylococcus aureus (MTCC3160) and Enterococcusi fecalis as Gram-positive bacteria, and Escherichia coli (MTCC1652) and Klebsiella pneumonia as Gram-negative bacteria. Antifungal potential against Candida albicans, and Aspergillus albicans strains were also evaluated. The results revealed that compounds 3a and 3c showed strong significant activity relative to the reference against these bacterial and fungal strains." @default.
- W2024996448 created "2016-06-24" @default.
- W2024996448 creator A5046297819 @default.
- W2024996448 creator A5050111698 @default.
- W2024996448 date "2014-03-25" @default.
- W2024996448 modified "2023-09-30" @default.
- W2024996448 title "New pyrano[2,3-<i>c</i>]pyridazine derivatives with antimicrobial activity synthesized using piperidine as the organocatalyst" @default.
- W2024996448 cites W1963674188 @default.
- W2024996448 cites W1969964192 @default.
- W2024996448 cites W1985424949 @default.
- W2024996448 cites W2002150211 @default.
- W2024996448 cites W2006159098 @default.
- W2024996448 cites W2017496419 @default.
- W2024996448 cites W2028232977 @default.
- W2024996448 cites W2057568851 @default.
- W2024996448 cites W2068207025 @default.
- W2024996448 cites W2075014255 @default.
- W2024996448 cites W2075131015 @default.
- W2024996448 cites W2076724108 @default.
- W2024996448 cites W2078620397 @default.
- W2024996448 cites W2085482737 @default.
- W2024996448 cites W2091343564 @default.
- W2024996448 cites W2091346565 @default.
- W2024996448 cites W2095397920 @default.
- W2024996448 cites W2099917949 @default.
- W2024996448 cites W2101257297 @default.
- W2024996448 cites W2174840819 @default.
- W2024996448 cites W2231831983 @default.
- W2024996448 cites W2950738497 @default.
- W2024996448 cites W2951210581 @default.
- W2024996448 doi "https://doi.org/10.3109/14756366.2013.877896" @default.
- W2024996448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24666292" @default.
- W2024996448 hasPublicationYear "2014" @default.
- W2024996448 type Work @default.
- W2024996448 sameAs 2024996448 @default.
- W2024996448 citedByCount "11" @default.
- W2024996448 countsByYear W20249964482015 @default.
- W2024996448 countsByYear W20249964482019 @default.
- W2024996448 countsByYear W20249964482021 @default.
- W2024996448 countsByYear W20249964482022 @default.
- W2024996448 countsByYear W20249964482023 @default.
- W2024996448 crossrefType "journal-article" @default.
- W2024996448 hasAuthorship W2024996448A5046297819 @default.
- W2024996448 hasAuthorship W2024996448A5050111698 @default.
- W2024996448 hasConcept C104317684 @default.
- W2024996448 hasConcept C178790620 @default.
- W2024996448 hasConcept C185592680 @default.
- W2024996448 hasConcept C21951064 @default.
- W2024996448 hasConcept C2776933286 @default.
- W2024996448 hasConcept C2777355660 @default.
- W2024996448 hasConcept C2777762789 @default.
- W2024996448 hasConcept C2779321679 @default.
- W2024996448 hasConcept C2780104969 @default.
- W2024996448 hasConcept C2780827033 @default.
- W2024996448 hasConcept C2780917455 @default.
- W2024996448 hasConcept C2781462491 @default.
- W2024996448 hasConcept C4937899 @default.
- W2024996448 hasConcept C501593827 @default.
- W2024996448 hasConcept C523546767 @default.
- W2024996448 hasConcept C54355233 @default.
- W2024996448 hasConcept C547475151 @default.
- W2024996448 hasConcept C55493867 @default.
- W2024996448 hasConcept C71240020 @default.
- W2024996448 hasConcept C86803240 @default.
- W2024996448 hasConcept C89423630 @default.
- W2024996448 hasConceptScore W2024996448C104317684 @default.
- W2024996448 hasConceptScore W2024996448C178790620 @default.
- W2024996448 hasConceptScore W2024996448C185592680 @default.
- W2024996448 hasConceptScore W2024996448C21951064 @default.
- W2024996448 hasConceptScore W2024996448C2776933286 @default.
- W2024996448 hasConceptScore W2024996448C2777355660 @default.
- W2024996448 hasConceptScore W2024996448C2777762789 @default.
- W2024996448 hasConceptScore W2024996448C2779321679 @default.
- W2024996448 hasConceptScore W2024996448C2780104969 @default.
- W2024996448 hasConceptScore W2024996448C2780827033 @default.
- W2024996448 hasConceptScore W2024996448C2780917455 @default.
- W2024996448 hasConceptScore W2024996448C2781462491 @default.
- W2024996448 hasConceptScore W2024996448C4937899 @default.
- W2024996448 hasConceptScore W2024996448C501593827 @default.
- W2024996448 hasConceptScore W2024996448C523546767 @default.
- W2024996448 hasConceptScore W2024996448C54355233 @default.
- W2024996448 hasConceptScore W2024996448C547475151 @default.
- W2024996448 hasConceptScore W2024996448C55493867 @default.
- W2024996448 hasConceptScore W2024996448C71240020 @default.
- W2024996448 hasConceptScore W2024996448C86803240 @default.
- W2024996448 hasConceptScore W2024996448C89423630 @default.
- W2024996448 hasIssue "1" @default.
- W2024996448 hasLocation W20249964481 @default.
- W2024996448 hasLocation W20249964482 @default.
- W2024996448 hasOpenAccess W2024996448 @default.
- W2024996448 hasPrimaryLocation W20249964481 @default.
- W2024996448 hasRelatedWork W2024996448 @default.
- W2024996448 hasRelatedWork W2055492175 @default.
- W2024996448 hasRelatedWork W2084049013 @default.
- W2024996448 hasRelatedWork W2146317305 @default.
- W2024996448 hasRelatedWork W2399363405 @default.
- W2024996448 hasRelatedWork W2580154336 @default.
- W2024996448 hasRelatedWork W2899704430 @default.