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- W2024996587 abstract "Necrotizing myopathy is a rare form of statin myopathy. In these patients, discontinuation of the drug does not translate into recovery even after several months and necrosis without inflammation is found in muscle biopsy. This entity responds to steroid and immunotherapy. The other known causes of necrotizing inflammatory myopathy include overlap syndromes, particularly in the setting of signal recognition particle (SRP) antibodies and also paraneoplastic myopathies. We report a male and a female patients aged 58 and 78 years old, who were on statin treatment for a period of 4 and 5 years, respectively. They developed muscle weakness with a limb girdle distribution and respiratory and neck weakness in the female patient who were more affected. CK were highly elevated and EMG showed myopathic potentials with denervation at rest. Muscle biopsy showed necrosis without inflammtion Both patients met the following criteria for immune-mediated necrotizing myopathy: (1) proximal muscle weakness occurring during or after treatment with statins (2) elevated serum creatine kinase (CK) (3) persistence of weakness and elevated CK despite discontinuation of the statin; (4) improvement with immunosuppressive agents; and (5) muscle biopsy showing necrotizing myopathy without significant inflammation. The man were treated with steroids with complete recovery in four months, and the female,who were more severely ill, did not respond to therapy. We present two patients with immune-mediated necrotizing myopathy associated to statins. These are a rare subgroup of patients with an immune-mediated necrotizing myopathy that does not improve after discontinuation of the drug and requires aggressive treatment with immunosuppressive agents.Awareness and early recognition of this disease is very important because responds to immunotherapy." @default.
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- W2024996587 date "2011-10-01" @default.
- W2024996587 modified "2023-09-27" @default.
- W2024996587 title "P5.24 Immune-mediated Necrotizing Myopathy Associated with Statins: Presentation of two cases and review of the literature" @default.
- W2024996587 doi "https://doi.org/10.1016/j.nmd.2011.06.1053" @default.
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