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- W2024996841 abstract "Myofibroblasts (MFBs) are smooth muscle-like cells that provide contractile force required for tissue repair during wound healing. The leading agonist for MFB differentiation is transforming growth factor β1 (TGFβ1) that induces transcription of genes encoding smooth muscle α-actin (SMαA) and interstitial collagen that are markers for MFB differentiation. TGFβ1 augments activation of Smad transcription factors, pro-survival Akt kinase, and p38 MAP kinase as well as Wingless/int (Wnt) developmental signaling. These actions conspire to activate β-catenin needed for expression of cyclin D, laminin, fibronectin, and metalloproteinases that aid in repairing epithelial cells and their associated basement membranes. Importantly, β-catenin also provides a feed-forward stimulus that amplifies local TGFβ1 autocrine/paracrine signaling causing transition of mesenchymal stromal cells, pericytes, and epithelial cells into contractile MFBs. Complex, mutually interactive mechanisms have evolved that permit several mammalian cell types to activate the SMαA promoter and undergo MFB differentiation. These molecular controls will be reviewed with an emphasis on the dynamic interplay between serum response factor, TGFβ1-activated Smads, Wnt-activated β-catenin, p38/calcium-activated NFAT protein, and the RNA-binding proteins, Purα, Purβ, and YB-1, in governing transcriptional and translational control of the SMαA gene in injury-activated MFBs." @default.
- W2024996841 created "2016-06-24" @default.
- W2024996841 creator A5043926325 @default.
- W2024996841 creator A5062669708 @default.
- W2024996841 date "2013-03-28" @default.
- W2024996841 modified "2023-10-06" @default.
- W2024996841 title "Dynamic Interplay of Smooth Muscle α-Actin Gene-Regulatory Proteins Reflects the Biological Complexity of Myofibroblast Differentiation" @default.
- W2024996841 cites W1505411117 @default.
- W2024996841 cites W1510352950 @default.
- W2024996841 cites W1588127651 @default.
- W2024996841 cites W1840439659 @default.
- W2024996841 cites W1928995207 @default.
- W2024996841 cites W1964195356 @default.
- W2024996841 cites W1965943806 @default.
- W2024996841 cites W1966672647 @default.
- W2024996841 cites W1966760994 @default.
- W2024996841 cites W1969361725 @default.
- W2024996841 cites W1970126684 @default.
- W2024996841 cites W1973242488 @default.
- W2024996841 cites W1974089939 @default.
- W2024996841 cites W1977507384 @default.
- W2024996841 cites W1978547782 @default.
- W2024996841 cites W1979147243 @default.
- W2024996841 cites W1979475230 @default.
- W2024996841 cites W1981269419 @default.
- W2024996841 cites W1981416792 @default.
- W2024996841 cites W1983281361 @default.
- W2024996841 cites W1986052708 @default.
- W2024996841 cites W1988819058 @default.
- W2024996841 cites W1989387938 @default.
- W2024996841 cites W1992258392 @default.
- W2024996841 cites W1992813930 @default.
- W2024996841 cites W1993669722 @default.
- W2024996841 cites W1994238227 @default.
- W2024996841 cites W1995333503 @default.
- W2024996841 cites W1995592152 @default.
- W2024996841 cites W1996110208 @default.
- W2024996841 cites W1999455210 @default.
- W2024996841 cites W1999971302 @default.
- W2024996841 cites W2000328180 @default.
- W2024996841 cites W2003275250 @default.
- W2024996841 cites W2004296543 @default.
- W2024996841 cites W2005440804 @default.
- W2024996841 cites W2009507862 @default.
- W2024996841 cites W2010185965 @default.
- W2024996841 cites W2010433678 @default.
- W2024996841 cites W2015959969 @default.
- W2024996841 cites W2017946623 @default.
- W2024996841 cites W2019316370 @default.
- W2024996841 cites W2022493256 @default.
- W2024996841 cites W2023242680 @default.
- W2024996841 cites W2023687572 @default.
- W2024996841 cites W2024276071 @default.
- W2024996841 cites W2025029681 @default.
- W2024996841 cites W2026639078 @default.
- W2024996841 cites W2026829115 @default.
- W2024996841 cites W2038049104 @default.
- W2024996841 cites W2039229665 @default.
- W2024996841 cites W2039378503 @default.
- W2024996841 cites W2040108549 @default.
- W2024996841 cites W2041172831 @default.
- W2024996841 cites W2042555598 @default.
- W2024996841 cites W2045949722 @default.
- W2024996841 cites W2046821312 @default.
- W2024996841 cites W2046844405 @default.
- W2024996841 cites W2050053473 @default.
- W2024996841 cites W2050417522 @default.
- W2024996841 cites W2050645323 @default.
- W2024996841 cites W2051696368 @default.
- W2024996841 cites W2051788770 @default.
- W2024996841 cites W2052817643 @default.
- W2024996841 cites W2053837765 @default.
- W2024996841 cites W2057386289 @default.
- W2024996841 cites W2059348822 @default.
- W2024996841 cites W2060072724 @default.
- W2024996841 cites W2060671095 @default.
- W2024996841 cites W2061869453 @default.
- W2024996841 cites W2063769358 @default.
- W2024996841 cites W2071253898 @default.
- W2024996841 cites W2078977503 @default.
- W2024996841 cites W2079040538 @default.
- W2024996841 cites W2081356898 @default.
- W2024996841 cites W2081882866 @default.
- W2024996841 cites W2082837373 @default.
- W2024996841 cites W2083640893 @default.
- W2024996841 cites W2086046729 @default.
- W2024996841 cites W2089172191 @default.
- W2024996841 cites W2089697406 @default.
- W2024996841 cites W2090392605 @default.
- W2024996841 cites W2090765436 @default.
- W2024996841 cites W2092388342 @default.
- W2024996841 cites W2095125442 @default.
- W2024996841 cites W2096171314 @default.
- W2024996841 cites W2097569168 @default.
- W2024996841 cites W2097990861 @default.
- W2024996841 cites W2099128146 @default.
- W2024996841 cites W2099486691 @default.
- W2024996841 cites W2104002497 @default.