Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024997085> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2024997085 endingPage "362" @default.
- W2024997085 startingPage "357" @default.
- W2024997085 abstract "Brevatonal and Mediatorial are two synthetic curare-like preparations used in Europe since 1952. Brevatonal belongs to the leptocurare group, but compared to succinylcholme its action is slower and more prolonged. Its latent period is from one to three minutes, and its average duration is twenty minutes. It combines with thiobarbital without causing precipitation, and repeated doses do not have cumulative effect. Mediatonal has a rapid and prolonged action. It brings into play, by trigger action, changes in the electrical potential of thiobarbital, the leptocurares to the extent of 300 per cent, and the pachycurares 1000 per cent. It is non-toxic, but has a cumulative action if the doses are repeated within thirty-minute intervals. The electrical potential mediator property is used in the Brevatonal-Mediatonal combination in order to reduce, to an appreciable extent, the dosage of the curare-like substance, as well as the anaesthetics. We have used these preparations 106 times for various operative procedures. Special attention was given to their use in the more common types of operations, such as cholecystectomies, appendectomies, and tonsillectomies. There are certain features which are worth noting. A depolarization block due to Brevatonal is never accompanied by much fasciculation, even when administered prior to Pentothal induction. Respiratory depression was never very marked in our experience; and intubation was never a problem. In our opinion, this relaxant, as a curare-like agent of relatively long duration, should occupy an intermediate place between succinylcholine and decamethonium. With Mediatonal alone, satisfactory muscular relaxation can be obtained with a fairly large dose; the association of Brevatonal and Mediatonal, however, procures long anaesthesia with relatively small doses of the curare-like substance when complementary anaesthetics are used. Brevatonal fills a gap in the duration pattern, between succinylcholine and the curare-like substances of longer duration, it is admirably suited for operations that are neither too long nor too short, and especially suitable when intubation or muscular relaxation are required." @default.
- W2024997085 created "2016-06-24" @default.
- W2024997085 creator A5038964626 @default.
- W2024997085 creator A5073187312 @default.
- W2024997085 date "1956-10-01" @default.
- W2024997085 modified "2023-10-06" @default.
- W2024997085 title "Considerations cliniques sur Ľemploi de deux nouveaux curarisants de synthese le brevatonal et le mediatonal" @default.
- W2024997085 doi "https://doi.org/10.1007/bf03015279" @default.
- W2024997085 hasPublicationYear "1956" @default.
- W2024997085 type Work @default.
- W2024997085 sameAs 2024997085 @default.
- W2024997085 citedByCount "0" @default.
- W2024997085 crossrefType "journal-article" @default.
- W2024997085 hasAuthorship W2024997085A5038964626 @default.
- W2024997085 hasAuthorship W2024997085A5073187312 @default.
- W2024997085 hasBestOaLocation W20249970851 @default.
- W2024997085 hasConcept C112758219 @default.
- W2024997085 hasConcept C124952713 @default.
- W2024997085 hasConcept C126322002 @default.
- W2024997085 hasConcept C142362112 @default.
- W2024997085 hasConcept C170493617 @default.
- W2024997085 hasConcept C185592680 @default.
- W2024997085 hasConcept C2775939251 @default.
- W2024997085 hasConcept C2778506399 @default.
- W2024997085 hasConcept C2778970341 @default.
- W2024997085 hasConcept C42219234 @default.
- W2024997085 hasConcept C71924100 @default.
- W2024997085 hasConceptScore W2024997085C112758219 @default.
- W2024997085 hasConceptScore W2024997085C124952713 @default.
- W2024997085 hasConceptScore W2024997085C126322002 @default.
- W2024997085 hasConceptScore W2024997085C142362112 @default.
- W2024997085 hasConceptScore W2024997085C170493617 @default.
- W2024997085 hasConceptScore W2024997085C185592680 @default.
- W2024997085 hasConceptScore W2024997085C2775939251 @default.
- W2024997085 hasConceptScore W2024997085C2778506399 @default.
- W2024997085 hasConceptScore W2024997085C2778970341 @default.
- W2024997085 hasConceptScore W2024997085C42219234 @default.
- W2024997085 hasConceptScore W2024997085C71924100 @default.
- W2024997085 hasIssue "4" @default.
- W2024997085 hasLocation W20249970851 @default.
- W2024997085 hasOpenAccess W2024997085 @default.
- W2024997085 hasPrimaryLocation W20249970851 @default.
- W2024997085 hasRelatedWork W2134403722 @default.
- W2024997085 hasRelatedWork W2165556370 @default.
- W2024997085 hasRelatedWork W2216608967 @default.
- W2024997085 hasRelatedWork W2222645363 @default.
- W2024997085 hasRelatedWork W2288818457 @default.
- W2024997085 hasRelatedWork W2549135832 @default.
- W2024997085 hasRelatedWork W2748952813 @default.
- W2024997085 hasRelatedWork W2899084033 @default.
- W2024997085 hasRelatedWork W4312920164 @default.
- W2024997085 hasRelatedWork W44819383 @default.
- W2024997085 hasVolume "3" @default.
- W2024997085 isParatext "false" @default.
- W2024997085 isRetracted "false" @default.
- W2024997085 magId "2024997085" @default.
- W2024997085 workType "article" @default.